LRRK1 leucine rich repeat kinase 1

Gene ID: 79705, updated on 17-Jun-2024
Gene type: protein coding
Also known as: OSMD; RIPK6; Roco1

Summary

This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. GeneReviews: Not available
Osteosclerotic metaphyseal dysplasia MedGen: C3554665OMIM: 615198GeneReviews: Not available	See labs

Genomic context

Location:: 15q26.3

Sequence:: Chromosome: 15; NC_000015.10 (100919357..101078257)

Total number of exons:: 34

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for LRRK1 variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
MedGen
Related information in MedGen
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
RefSeqGene
Link to Nucleotide RefSeqGenes
Variation Viewer
Related Variants

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