C5AR1 complement C5a receptor 1

Gene ID: 728, updated on 28-Oct-2024
Gene type: protein coding
Also known as: C5A; C5AR; C5R1; CD88

Summary

Enables G protein-coupled receptor activity and complement component C5a receptor activity. Involved in several processes, including complement component C5a signaling pathway; mRNA transcription by RNA polymerase II; and positive regulation of ERK1 and ERK2 cascade. Located in apical part of cell and basolateral plasma membrane. Biomarker of Alzheimer's disease; asthma; chronic obstructive pulmonary disease; rhinitis; and severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Oct 2024]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Genome wide association scan for chronic periodontitis implicates novel locus. GeneReviews: Not available

Genomic context

Location:: 19q13.32

Sequence:: Chromosome: 19; NC_000019.10 (47307477..47322066)

Total number of exons:: 4

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for C5AR1 variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
Variation Viewer
Related Variants

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