TLE4 TLE family member 4, transcriptional corepressor
Gene ID: 7091, updated on 14-Nov-2024Gene type: protein coding
Also known as: ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl)
- See all available tests in GTR for this gene
- Go to complete Gene record for TLE4
- Go to Variation Viewer for TLE4 variants
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Nov 2024]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. GeneReviews: Not available | |
| Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. GeneReviews: Not available | |
| Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. GeneReviews: Not available | |
| Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. GeneReviews: Not available |
Genomic context
- Location:
- 9q21.31
- Sequence:
- Chromosome: 9; NC_000009.12 (79571965..79726882)
- Total number of exons:
- 29
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for TLE4 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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