TCF7L2 transcription factor 7 like 2
Gene ID: 6934, updated on 3-Nov-2024Gene type: protein coding
Also known as: TCF4; TCF-4
- See all available tests in GTR for this gene
- Go to complete Gene record for TCF7L2
- Go to Variation Viewer for TCF7L2 variants
Summary
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. GeneReviews: Not available | |
| A genome-wide association study identifies novel risk loci for type 2 diabetes. GeneReviews: Not available | |
| A genome-wide association study of the metabolic syndrome in Indian Asian men. GeneReviews: Not available | |
| A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. GeneReviews: Not available | |
| A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. GeneReviews: Not available | |
| Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. GeneReviews: Not available | |
| Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. GeneReviews: Not available | |
| Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. GeneReviews: Not available | |
| Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. GeneReviews: Not available | |
| Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. GeneReviews: Not available | |
| Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. GeneReviews: Not available | |
| Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. GeneReviews: Not available | |
| Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. GeneReviews: Not available | |
| Genome-wide association study identifies three novel loci for type 2 diabetes. GeneReviews: Not available | |
| Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. GeneReviews: Not available | |
| Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. GeneReviews: Not available | |
| Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. GeneReviews: Not available | |
| Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. GeneReviews: Not available | |
| Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. GeneReviews: Not available | |
| Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. GeneReviews: Not available | |
| Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. GeneReviews: Not available | |
| Large-scale genotyping identifies 41 new loci associated with breast cancer risk. GeneReviews: Not available | |
| Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. GeneReviews: Not available | |
| Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes. GeneReviews: Not available | |
| New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. GeneReviews: Not available | |
| Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. GeneReviews: Not available | |
| Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. GeneReviews: Not available | |
| Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. GeneReviews: Not available | |
| The TCF7L2 diabetes risk variant is associated with HbA₁(C) levels: a genome-wide association meta-analysis. GeneReviews: Not available | |
| Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. GeneReviews: Not available | |
| Type 2 diabetes mellitus | not available |
| Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. GeneReviews: Not available | |
| Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study. GeneReviews: Not available |
Copy number response
| Description |
|---|
| Copy number response Triplosensitivity No evidence available (Last evaluated 2019-03-27) ClinGen Genome Curation PageHaploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2019-03-27) ClinGen Genome Curation PagePubMed |
Genomic context
- Location:
- 10q25.2-q25.3
- Sequence:
- Chromosome: 10; NC_000010.11 (112950247..113167678)
- Total number of exons:
- 20
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for TCF7L2 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- TCF7L2 database
- Variation ViewerRelated Variants
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