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STK4 serine/threonine kinase 4

Gene ID: 6789, updated on 28-Oct-2024
Gene type: protein coding
Also known as: KRS2; MST1; YSK3

Summary

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

Genomic context

Location:
20q13.12
Sequence:
Chromosome: 20; NC_000020.11 (44966512..45080021)
Total number of exons:
15

Links

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