SRC SRC proto-oncogene, non-receptor tyrosine kinase
Gene ID: 6714, updated on 17-Jun-2024Gene type: protein coding
Also known as: ASV; SRC1; THC6; c-SRC; p60-Src
- See all available tests in GTR for this gene
- Go to complete Gene record for SRC
- Go to Variation Viewer for SRC variants
Summary
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Colorectal cancer | See labs |
| Genome-wide association study of retinopathy in individuals without diabetes. GeneReviews: Not available | |
| Thrombocytopenia 6 | See labs |
Genomic context
- Location:
- 20q11.23
- Sequence:
- Chromosome: 20; NC_000020.11 (37344699..37406050)
- Total number of exons:
- 21
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for SRC variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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