ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

Gene ID: 64411, updated on 17-Aug-2024
Gene type: protein coding
Also known as: DRAG1; CENTD3

Summary

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. GeneReviews: Not available

Genomic context

Location:: 5q31.3

Sequence:: Chromosome: 5; NC_000005.10 (141653402..141682230, complement)

Total number of exons:: 35

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for ARAP3 variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
RefSeqGene
Link to Nucleotide RefSeqGenes
Variation Viewer
Related Variants

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