PKNOX2 PBX/knotted 1 homeobox 2
Gene ID: 63876, updated on 17-Jun-2024Gene type: protein coding
Also known as: PREP2
- See all available tests in GTR for this gene
- Go to complete Gene record for PKNOX2
- Go to Variation Viewer for PKNOX2 variants
Summary
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. GeneReviews: Not available | |
| Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. GeneReviews: Not available | |
| Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. GeneReviews: Not available | |
| Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. GeneReviews: Not available | |
| Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk. GeneReviews: Not available | |
| Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. GeneReviews: Not available | |
| PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies. GeneReviews: Not available | |
| The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. GeneReviews: Not available |
Genomic context
- Location:
- 11q24.2
- Sequence:
- Chromosome: 11; NC_000011.10 (125164751..125433389)
- Total number of exons:
- 17
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for PKNOX2 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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