ROS1 ROS proto-oncogene 1, receptor tyrosine kinase
Gene ID: 6098, updated on 27-Aug-2024Gene type: protein coding
Also known as: ROS; MCF3; c-ros-1
- See all available tests in GTR for this gene
- Go to complete Gene record for ROS1
- Go to Variation Viewer for ROS1 variants
Summary
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
Description | Tests |
---|---|
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. GeneReviews: Not available | |
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. GeneReviews: Not available |
Genomic context
- Location:
- 6q22.1
- Sequence:
- Chromosome: 6; NC_000006.12 (117287353..117425942, complement)
- Total number of exons:
- 46
Variation
Resource | Links for this gene |
---|---|
ClinVar | Variants reported to ClinVar |
dbVar | Studies and variants |
SNP | Variation Viewer for ROS1 variants |
Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.