BCL3 BCL3 transcription coactivator
Gene ID: 602, updated on 2-Nov-2024Gene type: protein coding
Also known as: BCL4; D19S37
- See all available tests in GTR for this gene
- Go to complete Gene record for BCL3
- Go to Variation Viewer for BCL3 variants
Summary
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. GeneReviews: Not available | |
| Leukemia/lymphoma, B-cell, 3 MedGen: CN375896GeneReviews: Not available | not available |
| Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies. GeneReviews: Not available | |
| SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. GeneReviews: Not available |
Genomic context
- Location:
- 19q13.32
- Sequence:
- Chromosome: 19; NC_000019.10 (44747705..44760044)
- Total number of exons:
- 10
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for BCL3 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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