PSMA4 proteasome 20S subunit alpha 4
Gene ID: 5685, updated on 14-Nov-2024Gene type: protein coding
Also known as: HC9; PSC9; HsT17706
- See all available tests in GTR for this gene
- Go to complete Gene record for PSMA4
- Go to Variation Viewer for PSMA4 variants
Summary
This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. GeneReviews: Not available | |
| Biological insights from 108 schizophrenia-associated genetic loci. GeneReviews: Not available | |
| Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. GeneReviews: Not available | |
| Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. GeneReviews: Not available | |
| Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. GeneReviews: Not available | |
| IREB2 and GALC are Associated with Pulmonary Artery Enlargement in Chronic Obstructive Pulmonary Disease. GeneReviews: Not available |
Genomic context
- Location:
- 15q25.1
- Sequence:
- Chromosome: 15; NC_000015.10 (78540405..78552417)
- Total number of exons:
- 10
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for PSMA4 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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