EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
Gene ID: 56478, updated on 10-Oct-2024Gene type: protein coding
Also known as: 4E-T; Clast4
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- Go to complete Gene record for EIF4ENIF1
- Go to Variation Viewer for EIF4ENIF1 variants
Summary
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Associated conditions
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Description | Tests |
---|---|
Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. GeneReviews: Not available |
Genomic context
- Location:
- 22q12.2
- Sequence:
- Chromosome: 22; NC_000022.11 (31436963..31493568, complement)
- Total number of exons:
- 22
Variation
Resource | Links for this gene |
---|---|
ClinVar | Variants reported to ClinVar |
dbVar | Studies and variants |
SNP | Variation Viewer for EIF4ENIF1 variants |
Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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