SULF2 sulfatase 2

Gene ID: 55959, updated on 28-Oct-2024
Gene type: protein coding
Also known as: HSULF-2

Summary

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Common variation in GPC5 is associated with acquired nephrotic syndrome. GeneReviews: Not available
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. GeneReviews: Not available

Genomic context

Location:: 20q13.12

Sequence:: Chromosome: 20; NC_000020.11 (47657406..47786627, complement)

Total number of exons:: 24

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for SULF2 variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
Variation Viewer
Related Variants

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