U.S. flag

An official website of the United States government

GTR Home > Genes

PKN1 protein kinase N1

Gene ID: 5585, updated on 6-Oct-2024
Gene type: protein coding
Also known as: DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA

Summary

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Genomic context

Location:
19p13.12
Sequence:
Chromosome: 19; NC_000019.10 (14433306..14471859)
Total number of exons:
23

Links

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.