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PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta

Gene ID: 5577, updated on 14-Nov-2024
Gene type: protein coding
Also known as: PRKAR2; RII-BETA

Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Genome-wide interaction study of smoking and bladder cancer risk.
GeneReviews: Not available
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
GeneReviews: Not available
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
GeneReviews: Not available

Genomic context

Location:
7q22.3
Sequence:
Chromosome: 7; NC_000007.14 (107044705..107161811)
Total number of exons:
11

Links

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