CHAC2 ChaC glutathione specific gamma-glutamylcyclotransferase 2
Gene ID: 494143, updated on 17-Sep-2024Gene type: protein coding
Also known as: GCG1
- See all available tests in GTR for this gene
- Go to complete Gene record for CHAC2
- Go to Variation Viewer for CHAC2 variants
Summary
The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016]
Genomic context
- Location:
- 2p16.2
- Sequence:
- Chromosome: 2; NC_000002.12 (53767783..53775196)
- Total number of exons:
- 3
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for CHAC2 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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