HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
Gene ID: 3118, updated on 2-Nov-2024Gene type: protein coding
Also known as: DQA1; HLA-DCA; HLA-DXA; HLADQA2; DC-alpha; DX-ALPHA
- See all available tests in GTR for this gene
- Go to complete Gene record for HLA-DQA2
- Go to Variation Viewer for HLA-DQA2 variants
Summary
This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. GeneReviews: Not available | |
| A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. GeneReviews: Not available | |
| A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese. GeneReviews: Not available | |
| A genome-wide association study reveals ARL15, a novel non-HLA susceptibility gene for rheumatoid arthritis in North Indians. GeneReviews: Not available | |
| A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. GeneReviews: Not available | |
| Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. GeneReviews: Not available | |
| Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. GeneReviews: Not available | |
| Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. GeneReviews: Not available | |
| Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. GeneReviews: Not available | |
| Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility. GeneReviews: Not available | |
| Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. GeneReviews: Not available | |
| Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. GeneReviews: Not available | |
| Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis. GeneReviews: Not available | |
| GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. GeneReviews: Not available | |
| Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. GeneReviews: Not available | |
| New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study. GeneReviews: Not available | |
| Novel associations for hypothyroidism include known autoimmune risk loci. GeneReviews: Not available | |
| Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. GeneReviews: Not available | |
| Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. GeneReviews: Not available | |
| Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. GeneReviews: Not available | |
| Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. GeneReviews: Not available |
Genomic context
- Location:
- 6p21.32
- Sequence:
- Chromosome: 6; NC_000006.12 (32741391..32747198)
- Total number of exons:
- 5
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for HLA-DQA2 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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