HDAC1 histone deacetylase 1
Gene ID: 3065, updated on 14-Nov-2024Gene type: protein coding
Also known as: HD1; RPD3; KDAC1; GON-10; RPD3L1
Summary
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
Genomic context
- Location:
- 1p35.2-p35.1
- Sequence:
- Chromosome: 1; NC_000001.11 (32292083..32333626)
- Total number of exons:
- 15
Variation
| Resource | Links for this gene |
|---|---|
| SNP | Variation Viewer for HDAC1 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
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