TOX3 TOX high mobility group box family member 3
Gene ID: 27324, updated on 17-Sep-2024Gene type: protein coding
Also known as: CAGF9; TNRC9
- See all available tests in GTR for this gene
- Go to complete Gene record for TOX3
- Go to Variation Viewer for TOX3 variants
Summary
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A combined analysis of genome-wide association studies in breast cancer. GeneReviews: Not available | |
| A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. GeneReviews: Not available | |
| A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). GeneReviews: Not available | |
| Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. GeneReviews: Not available | |
| Genome-wide association studies identify four ER negative-specific breast cancer risk loci. GeneReviews: Not available | |
| Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. GeneReviews: Not available | |
| Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. GeneReviews: Not available | |
| Genome-wide association study identifies five new breast cancer susceptibility loci. GeneReviews: Not available | |
| Genome-wide association study identifies novel breast cancer susceptibility loci. GeneReviews: Not available | |
| Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. GeneReviews: Not available | |
| Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. GeneReviews: Not available | |
| Genome-wide association study of breast cancer in the Japanese population. GeneReviews: Not available | |
| Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium. GeneReviews: Not available | |
| Large-scale genotyping identifies 41 new loci associated with breast cancer risk. GeneReviews: Not available | |
| Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. GeneReviews: Not available |
Genomic context
- Location:
- 16q12.1
- Sequence:
- Chromosome: 16; NC_000016.10 (52436416..52547802, complement)
- Total number of exons:
- 10
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for TOX3 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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