APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2
Gene ID: 27301, updated on 2-Nov-2024Gene type: protein coding
Also known as: APE2; XTH2; ZGRF2; APEXL2
Summary
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Genomic context
- Location:
- Xp11.21
- Sequence:
- Chromosome: X; NC_000023.11 (55000363..55009057)
- Total number of exons:
- 6
Variation
| Resource | Links for this gene |
|---|---|
| SNP | Variation Viewer for APEX2 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
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