DICER1 dicer 1, ribonuclease III
Gene ID: 23405, updated on 3-Nov-2024Gene type: protein coding
Also known as: DCR1; GLOW; MNG1; aviD; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
- See all available tests in GTR for this gene
- Go to complete Gene record for DICER1
- Go to Variation Viewer for DICER1 variants
Summary
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Euthyroid goiter | not available |
| Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. GeneReviews: Not available | |
| Genome-wide association of lipid-lowering response to statins in combined study populations. GeneReviews: Not available | |
| Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome | not available |
| Pleuropulmonary blastoma | not available |
| Rhabdomyosarcoma, embryonal, 2 | not available |
Copy number response
| Description |
|---|
| Copy number response Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2022-02-09) ClinGen Genome Curation PagePubMedTriplosensitivity No evidence available (Last evaluated 2022-02-09) ClinGen Genome Curation Page |
Genomic context
- Location:
- 14q32.13
- Sequence:
- Chromosome: 14; NC_000014.9 (95086228..95158010, complement)
- Total number of exons:
- 36
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for DICER1 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- DICER1 database
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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