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NFASC neurofascin

Gene ID: 23114, updated on 10-Oct-2024
Gene type: protein coding
Also known as: NF; NRCAML; NEDCPMD

Summary

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
GeneReviews: Not available
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
GeneReviews: Not available
GWAS of dental caries patterns in the permanent dentition.
GeneReviews: Not available
NCK2 is significantly associated with opiates addiction in African-origin men.
GeneReviews: Not available
Neurodevelopmental disorder with central and peripheral motor dysfunction
MedGen: C5193049OMIM: 618356GeneReviews: Not available
not available

Genomic context

Location:
1q32.1
Sequence:
Chromosome: 1; NC_000001.11 (204828652..205022822)
Total number of exons:
37

Links

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