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PPM1E protein phosphatase, Mg2+/Mn2+ dependent 1E

Gene ID: 22843, updated on 2-Nov-2024
Gene type: protein coding
Also known as: POPX1; PP2CH; caMKN; CAMKPN; CaMKP-N

Summary

This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
GeneReviews: Not available
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
GeneReviews: Not available
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
GeneReviews: Not available

Genomic context

Location:
17q22
Sequence:
Chromosome: 17; NC_000017.11 (58755854..58985179)
Total number of exons:
8

Links

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