SLC30A8 solute carrier family 30 member 8
Gene ID: 169026, updated on 17-Jun-2024Gene type: protein coding
Also known as: ZNT8; ZnT-8
- See all available tests in GTR for this gene
- Go to complete Gene record for SLC30A8
- Go to Variation Viewer for SLC30A8 variants
Summary
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. GeneReviews: Not available | |
| A genome-wide association study identifies novel risk loci for type 2 diabetes. GeneReviews: Not available | |
| A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. GeneReviews: Not available | |
| A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. GeneReviews: Not available | |
| Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. GeneReviews: Not available | |
| Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. GeneReviews: Not available | |
| Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. GeneReviews: Not available | |
| Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. GeneReviews: Not available | |
| Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. GeneReviews: Not available | |
| Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. GeneReviews: Not available | |
| Genome-wide association study and meta-analysis of intraocular pressure. GeneReviews: Not available | |
| Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. GeneReviews: Not available | |
| Genome-wide association study identifies three novel loci for type 2 diabetes. GeneReviews: Not available | |
| Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. GeneReviews: Not available | |
| Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. GeneReviews: Not available | |
| New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. GeneReviews: Not available | |
| Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study. GeneReviews: Not available | |
| Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. GeneReviews: Not available | |
| Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. GeneReviews: Not available | |
| Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. GeneReviews: Not available | |
| Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. GeneReviews: Not available | |
| Type 2 diabetes mellitus | See labs |
Genomic context
- Location:
- 8q24.11
- Sequence:
- Chromosome: 8; NC_000008.11 (116950217..117176714)
- Total number of exons:
- 13
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for SLC30A8 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- SLC30A8 database
- Variation ViewerRelated Variants
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