CYP2C9 cytochrome P450 family 2 subfamily C member 9
Gene ID: 1559, updated on 28-Oct-2024Gene type: protein coding
Also known as: CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9; P450IIC9
- See all available tests in GTR for this gene
- Go to complete Gene record for CYP2C9
- Go to Variation Viewer for CYP2C9 variants
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. GeneReviews: Not available | |
| A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. GeneReviews: Not available | |
| An atlas of genetic influences on human blood metabolites. GeneReviews: Not available | |
| Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. GeneReviews: Not available | |
| Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. GeneReviews: Not available | |
| Dronabinol response MedGen: CN258190GeneReviews: Not available | See labs |
| Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. GeneReviews: Not available | |
| Flurbiprofen response MedGen: CN258139GeneReviews: Not available | See labs |
| Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. GeneReviews: Not available | |
| Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. GeneReviews: Not available | |
| Genome-wide association study of antibody response to smallpox vaccine. GeneReviews: Not available | |
| Lesinurad response MedGen: CN248784GeneReviews: Not available | See labs |
| Piroxicam response MedGen: CN258188GeneReviews: Not available | See labs |
| Warfarin response | See labs |
Genomic context
- Location:
- 10q23.33
- Sequence:
- Chromosome: 10; NC_000010.11 (94938658..94990091)
- Total number of exons:
- 9
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for CYP2C9 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- CYP2C9 database
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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