CRP C-reactive protein
Gene ID: 1401, updated on 17-Jun-2024Gene type: protein coding
Also known as: PTX1
- See all available tests in GTR for this gene
- Go to complete Gene record for CRP
- Go to Variation Viewer for CRP variants
Summary
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. GeneReviews: Not available | |
| A genome-wide association study identifies protein quantitative trait loci (pQTLs). GeneReviews: Not available | |
| Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? GeneReviews: Not available | |
| C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. GeneReviews: Not available | |
| Common Variants in the CRP Promoter are Associated with a High C-Reactive Protein Level in Kawasaki Disease. GeneReviews: Not available | |
| Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. GeneReviews: Not available | |
| Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. GeneReviews: Not available | |
| Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. GeneReviews: Not available | |
| Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. GeneReviews: Not available | |
| Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. GeneReviews: Not available | |
| Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment. GeneReviews: Not available | |
| Genome-wide association with select biomarker traits in the Framingham Heart Study. GeneReviews: Not available | |
| Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. GeneReviews: Not available | |
| Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. GeneReviews: Not available | |
| New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis. GeneReviews: Not available | |
| Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. GeneReviews: Not available |
Genomic context
- Location:
- 1q23.2
- Sequence:
- Chromosome: 1; NC_000001.11 (159712289..159714589, complement)
- Total number of exons:
- 3
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for CRP variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- CRP database
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.