AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Gene ID: 116986, updated on 17-Jun-2024Gene type: protein coding
Also known as: PIKE; GGAP2; CENTG1
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- Go to complete Gene record for AGAP2
- Go to Variation Viewer for AGAP2 variants
Summary
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Associated conditions
See all available tests in GTR for this gene
Description | Tests |
---|---|
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. GeneReviews: Not available |
Genomic context
- Location:
- 12q14.1
- Sequence:
- Chromosome: 12; NC_000012.12 (57723761..57742161, complement)
- Total number of exons:
- 20
Variation
Resource | Links for this gene |
---|---|
ClinVar | Variants reported to ClinVar |
dbVar | Studies and variants |
SNP | Variation Viewer for AGAP2 variants |
Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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