POLI DNA polymerase iota
Gene ID: 11201, updated on 10-Oct-2024Gene type: protein coding
Also known as: eta2; RAD30B; RAD3OB
- See all available tests in GTR for this gene
- Go to complete Gene record for POLI
- Go to Variation Viewer for POLI variants
Summary
The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion. [provided by RefSeq, May 2017]
Genomic context
- Location:
- 18q21.2
- Sequence:
- Chromosome: 18; NC_000018.10 (54269479..54321266)
- Total number of exons:
- 14
Variation
Resource | Links for this gene |
---|---|
ClinVar | Variants reported to ClinVar |
dbVar | Studies and variants |
SNP | Variation Viewer for POLI variants |
Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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