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TRIM3 tripartite motif containing 3

Gene ID: 10612, updated on 28-Oct-2024
Gene type: protein coding
Also known as: BERP; HAC1; RNF22; RNF97

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

Genomic context

Location:
11p15.4
Sequence:
Chromosome: 11; NC_000011.10 (6448613..6474459, complement)
Total number of exons:
16

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