Spermatogenic failure 87

Summary

Spermatogenic failure-87 (SPGF87) is characterized by male infertility, with total fertilization failure due to inability of mutant sperm to penetrate the zona pellucida. Infertility can be rescued by intracytoplasmic sperm injection without assisted oocyte activation (Hua et al., 2023). For a general phenotypic description and discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150). [from OMIM]

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Associated genes Help
Genes reported to contribute to the condition.

ACR
2 tests
Also known as: SPGF87, ACR
Summary: acrosin

Imported from Human Phenotype Ontology (HPO)

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Abnormality of the genitourinary system
- Male infertility
  Male infertility
  - MedGen UID: 5796
  - Concept ID: C0021364
  - Finding: Disease or Syndrome
  Abnormality of the genitourinary system
  See: Feature record | Search on this feature
- Ruffled acrosome
  Ruffled acrosome
  - MedGen UID: 1795480
  - Concept ID: C5563270
  - Finding: Finding
  Abnormality of the genitourinary system
  See: Feature record | Search on this feature

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