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GTR Home > Conditions/Phenotypes > Spermatogenic failure, X-linked, 7

Spermatogenic failure, X-linked, 7

Summary

X-linked spermatogenic failure-7 (SPGFX7) is characterized by male infertility due to significantly reduced sperm concentration and progressive motility, with abnormalities of the head and flagella. Patient sperm show insufficient individualization, excessive residual cytoplasm, and defects in acrosome development (Zhang et al., 2023). For a discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150). [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: BJHCC20A, CXorf48, SPGFX7, CT55
    Summary: cancer/testis antigen 55

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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