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GTR Home > Conditions/Phenotypes > Spermatogenic failure 74

Spermatogenic failure 74

Summary

Spermatogenic failure-74 (SPGF74) is characterized by nonobstructive azoospermia and male infertility due to complete meiotic arrest at the spermatocyte zygotene or pachytene stage. Some men exhibit reduced testicular volume and/or reduced testosterone level (Wyrwoll et al., 2022). For a general phenotypic description and discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150). [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: G7, MUTSH5, NG23, POF13, SPGF74, MSH5
    Summary: mutS homolog 5

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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