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GTR Home > Conditions/Phenotypes > Isolated focal non-epidermolytic palmoplantar keratoderma

Summary

A rare hereditary palmoplantar keratoderma characterized by focal hyperkeratotic lesions on the palms and soles. Histopathologic examination reveals prominent hyperkeratosis, thickened stratum spinosum with reduced stratum granulosum, disadhesion of cells in the suprabasal layers, elongation of rete ridges, and sparse lymphocyte infiltration in the dermis. [from ORDO]

Available tests

9 tests are in the database for this condition.

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Genes See tests for all associated and related genes

  • Also known as: FNEPPK2, OLMS, OLMS1, VRL3, TRPV3
    Summary: transient receptor potential cation channel subfamily V member 3

Clinical features

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