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GTR Home > Conditions/Phenotypes > Low density lipoprotein cholesterol level quantitative trait locus 3

Low density lipoprotein cholesterol level quantitative trait locus 3

Summary

Low density lipoprotein (LDL) cholesterol level quantitative trait locus 3 (LDLCQ3) represents regulation of LDL cholesterol by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR), the rate-limiting enzyme in the cholesterol biosynthesis pathway. HMGCR is inhibited by statins, a class of cholesterol-lowering drugs whose efficacy is influenced by variation in the HMGCR gene (summary by Yu et al., 2014). [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: LDLCQ3, LGMDR28, MYPLG, HMGCR
    Summary: 3-hydroxy-3-methylglutaryl-CoA reductase

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