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GTR Home > Conditions/Phenotypes > Cholestasis, intrahepatic, of pregnancy, 1

Cholestasis, intrahepatic, of pregnancy, 1

Synonyms
CHOLESTASIS, PREGNANCY-RELATED, 1

Summary

Intrahepatic cholestasis of pregnancy is a reversible form of cholestasis that occurs most often in the third trimester of pregnancy and recurs in 45 to 70% of subsequent pregnancies. Symptoms include pruritus, jaundice, increased serum bile salts, and abnormal liver enzymes, all of which resolve rapidly after delivery. However, the condition is associated with fetal complications, including placental insufficiency, premature labor, fetal distress, and intrauterine death. Some women with ICP may also be susceptible to oral contraceptive-induced cholestasis (OCIC) (summary by Pasmant et al., 2012). Genetic Heterogeneity of Intrahepatic Cholestasis of Pregnancy See also ICP3 (614972), caused by mutation in the ABCB4 gene (171060). [from OMIM]

Available tests

21 tests are in the database for this condition.

Clinical tests (21 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: ATPIC, BRIC, FIC1, ICP1, PFIC, PFIC1, ATP8B1
    Summary: ATPase phospholipid transporting 8B1

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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