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    SSTR5-AS1 SSTR5 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 146336, updated on 16-Jan-2024

    Summary

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    Official Symbol
    SSTR5-AS1provided by HGNC
    Official Full Name
    SSTR5 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:26502
    See related
    Ensembl:ENSG00000261713 AllianceGenome:HGNC:26502
    Gene type
    ncRNA
    RefSeq status
    PREDICTED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in adrenal (RPKM 2.9), stomach (RPKM 1.1) and 8 other tissues See more
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    Genomic context

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    Location:
    16p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1064081..1078731, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1075762..1090488, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1114081..1128731, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene lipase maturation factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1038856-1039356 Neighboring gene cytoplasmic endogenous regulator of oxidative phosphorylation 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1051902-1052558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1059983-1060602 Neighboring gene SRY-box transcription factor 8 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1064356-1064557 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1074897-1075411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1075412-1075925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1087280-1087789 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1097469-1098084 Neighboring gene Sharpr-MPRA regulatory region 13654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1113181-1113680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1119782-1120538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1121507-1122248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1128485-1129149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1132931-1133783 Neighboring gene somatostatin receptor 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6964 Neighboring gene C1q and TNF related 8 Neighboring gene uncharacterized LOC107984906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1157970-1158488

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA SSTR5-AS1 as a Prognostic Marker Promotes Cell Proliferation and Epithelial-to-Mesenchymal Transition in Prostate Cancer. Yuan S, et al. Crit Rev Eukaryot Gene Expr, 2023. PMID 36734853
    2. lncRNA SSTR5-AS1 Predicts Poor Prognosis and Contributes to the Progression of Esophageal Cancer. Hu Y, et al. Dis Markers, 2023. PMID 36726845, Free PMC Article
    3. Diagnostic and prognostic significance of long noncoding RNA SSTR5-AS1 in patients with gastric cancer. Cheng Y, et al. Eur Rev Med Pharmacol Sci, 2020 May. PMID 32495873
    4. Aberrant methylation-mediated downregulation of lncRNA SSTR5-AS1 promotes progression and metastasis of laryngeal squamous cell carcinoma. Wang B, et al. Epigenetics Chromatin, 2019 Jun 13. PMID 31196171, Free PMC Article
    5. Long non-coding RNA SSTR5-AS1 facilitates gemcitabine resistance via stabilizing NONO in gallbladder carcinoma. Xue Z, et al. Biochem Biophys Res Commun, 2020 Feb 19. PMID 31810606

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lncRNA SSTR5-AS1 Predicts Poor Prognosis and Contributes to the Progression of Esophageal Cancer.
      Title: lncRNA SSTR5-AS1 Predicts Poor Prognosis and Contributes to the Progression of Esophageal Cancer.
    2. LncRNA SSTR5-AS1 as a Prognostic Marker Promotes Cell Proliferation and Epithelial-to-Mesenchymal Transition in Prostate Cancer.
      Title: LncRNA SSTR5-AS1 as a Prognostic Marker Promotes Cell Proliferation and Epithelial-to-Mesenchymal Transition in Prostate Cancer.
    3. Diagnostic and prognostic significance of long noncoding RNA SSTR5-AS1 in patients with gastric cancer.
      Title: Diagnostic and prognostic significance of long noncoding RNA SSTR5-AS1 in patients with gastric cancer.
    4. Long non-coding RNA SSTR5-AS1 facilitates gemcitabine resistance via stabilizing NONO in gallbladder carcinoma.
      Title: Long non-coding RNA SSTR5-AS1 facilitates gemcitabine resistance via stabilizing NONO in gallbladder carcinoma.
    5. SSTR5-AS1 may play antitumor role in LSCC and may be regulated by the hypermethylation of the same CpG sites with SSTR5. SSTR5-AS1 inhibits laryngeal carcinoma cells proliferation, migration, and invasion.
      Title: Aberrant methylation-mediated downregulation of lncRNA SSTR5-AS1 promotes progression and metastasis of laryngeal squamous cell carcinoma.
    6. The present study suggests that SSTR5AS1 functions as a competing endogenous RNA to regulate CA2 by sponging miR15b5p for the development and prognosis of hepatitis B virus related hepatocellular carcinoma.
      Title: SSTR5‑AS1 functions as a ceRNA to regulate CA2 by sponging miR‑15b‑5p for the development and prognosis of HBV‑related hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • SSTR5 antisense RNA 1 (non-protein coding)

    Clone Names

    • FLJ32252

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027242.1 RNA Sequence

      Status: PREDICTED

      Source sequence(s)
      AC009041, AK056814, AW291498, BC068093
      Related
      ENST00000569832.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      1064081..1078731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      1075762..1090488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182510.1: Suppressed sequence

      Description
      NM_182510.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein and much of the transcript contains repetitive sequence (Alu and other repetitive sequences).
    Nucleotide Protein
    Heading Accession and Version

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