MYNN myoneurin [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYNNprovided by HGNC
Official Full Name: myoneurinprovided by HGNC
Primary source: HGNC:HGNC:14955
See related: Ensembl:ENSG00000085274 MIM:606042; AllianceGenome:HGNC:14955
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OSZF; SBBIZ1; ZBTB31; ZNF902
Summary: This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010]
Expression: Ubiquitous expression in bone marrow (RPKM 4.7), testis (RPKM 4.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q26.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (169773396..169789716)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (172557621..172573941)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (169491184..169507504)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comprehensive characterization of coding and non-coding single nucleotide polymorphisms of the Myoneurin (MYNN) gene using molecular dynamics simulation and docking approaches.
Title: Comprehensive characterization of coding and non-coding single nucleotide polymorphisms of the Myoneurin (MYNN) gene using molecular dynamics simulation and docking approaches.
there may exist an association between a combination of MYNN rs10936599 and TERC rs2293607 polymorphisms and development of bladder cancer in Turkish population.
Title: The Association of MYNN and TERC Gene Polymorphisms and Bladder Cancer in a Turkish Population.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic susceptibility to distinct bladder cancer subphenotypes.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple loci associated with bladder cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of seven loci affecting mean telomere length and their association with disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple common variants for celiac disease influencing immune gene expression. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MYNN_2243 (e-PCR)
- UniSTS:462365

G20242 (e-PCR)
- UniSTS:45391

A005B19 (e-PCR)
- UniSTS:45392

MYNN (e-PCR)
- UniSTS:505512

SHGC-77521 (e-PCR)
- UniSTS:8625

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: myoneurin

Names: zinc finger and BTB domain-containing protein 31; zinc finger protein with BTB/POZ domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001185118.2 → NP_001172047.1 myoneurin isoform A

See identical proteins and their annotated locations for NP_001172047.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) includes an additional exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform A).

Source sequence(s)

AC078795, AF148848, BX648128, DB134736

Consensus CDS

CCDS3207.1

UniProtKB/Swiss-Prot

B2R6C9, Q6QHA6, Q6QHA7, Q6R3G1, Q6R3G2, Q6R4A0, Q7Z716, Q7Z717, Q86Z11, Q86Z12, Q9NPC7, Q9NS01, Q9UIW8

Related

ENSP00000349150.3, ENST00000356716.8

Conserved Domains (5) summary

COG5189
Location:354 → 438

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:304 → 324

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:304 → 324

zf-C2H2; Zinc finger, C2H2 type

pfam00651
Location:14 → 115

BTB; BTB/POZ domain

pfam13465
Location:316 → 341

zf-H2C2_2; Zinc-finger double domain
NM_001185119.1 → NP_001172048.1 myoneurin isoform B

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform B), compared to isoform A.

Source sequence(s)

AB079778, AC078795, DB134736

Consensus CDS

CCDS54671.1

Related

ENSP00000440637.1, ENST00000544106.5

Conserved Domains (6) summary

COG5048
Location:385 → 535

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:354 → 438

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:304 → 324

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:304 → 324

zf-C2H2; Zinc finger, C2H2 type

pfam00651
Location:14 → 115

BTB; BTB/POZ domain

pfam13465
Location:316 → 341

zf-H2C2_2; Zinc-finger double domain
NM_018657.5 → NP_061127.1 myoneurin isoform A

See identical proteins and their annotated locations for NP_061127.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (A). Both variants 1 and 2 encode the same protein (isoform A).

Source sequence(s)

AC078795, BX648128, DB134736

Consensus CDS

CCDS3207.1

UniProtKB/Swiss-Prot

B2R6C9, Q6QHA6, Q6QHA7, Q6R3G1, Q6R3G2, Q6R4A0, Q7Z716, Q7Z717, Q86Z11, Q86Z12, Q9NPC7, Q9NS01, Q9UIW8

Related

ENSP00000326240.4, ENST00000349841.10

Conserved Domains (5) summary

COG5189
Location:354 → 438

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:304 → 324

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:304 → 324

zf-C2H2; Zinc finger, C2H2 type

pfam00651
Location:14 → 115

BTB; BTB/POZ domain

pfam13465
Location:316 → 341

zf-H2C2_2; Zinc-finger double domain

RNA

NR_033702.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site in an internal coding exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC078795, AK304281, BX648128, DB134736
NR_033703.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate splice site in an internal coding exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC078795, AC078802, AF155508, BX648128, DB134736