NUDT10 nudix hydrolase 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NUDT10provided by HGNC
Official Full Name: nudix hydrolase 10provided by HGNC
Primary source: HGNC:HGNC:17621
See related: Ensembl:ENSG00000122824 MIM:300527; AllianceGenome:HGNC:17621
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APS2; DIPP3a; DIPP3-alpha
Summary: This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]
Expression: Biased expression in testis (RPKM 20.6), brain (RPKM 8.6) and 6 other tissues See more
Orthologs: all
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Genomic context

Location:: Xp11.22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (51332231..51337525)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (50603515..50608810)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (51075083..51080377)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clinical correlations and prognostic value of Nudix hydroxylase 10 in patients with gastric cancer.
Title: Clinical correlations and prognostic value of Nudix hydroxylase 10 in patients with gastric cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: Validation of genome-wide prostate cancer associations in men of African descent.
Meta-analysis of gene-disease association. (HuGE Navigator)
Title: Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.
The NUDT10 gene, located on chromosome X, is preferentially expressed in the testis
Title: An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.
Cloning and characterisation of NUDT10 as a diadenosine polyphosphate-metabolising Nudix hydrolase.
Title: Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple newly identified loci associated with prostate cancer susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NUDT11 (e-PCR)
- UniSTS:498188

WI-13729 (e-PCR)
- UniSTS:34758

SHGC-24010 (e-PCR)
- UniSTS:34759

DXS7057 (e-PCR)
- UniSTS:64467

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables bis(5'-adenosyl)-hexaphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-adenosyl)-pentaphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphoinositol-polyphosphate diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphoinositol-polyphosphate diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables endopolyphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine hexaphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine pentaphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diphosphoinositol polyphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Names: diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha; diadenosine hexaphosphate hydrolase (AMP-forming); nucleoside diphosphate-linked moiety X motif 10; nudix (nucleoside diphosphate linked moiety X)-type motif 10; nudix motif 10

NP_001291892.1

EC 3.6.1.52

EC 3.6.1.60

NP_694853.1

EC 3.6.1.52

EC 3.6.1.60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304963.2 → NP_001291892.1 diphosphoinositol polyphosphate phosphohydrolase 3-alpha

See identical proteins and their annotated locations for NP_001291892.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC049383, BC050700, BX449265, CN399689

Consensus CDS

CCDS35278.1

UniProtKB/Swiss-Prot

A8K7D7, D3DX69, Q86VK1, Q86VR0, Q8NFP7

UniProtKB/TrEMBL

B2RE29

Related

ENSP00000348831.2, ENST00000356450.3

Conserved Domains (1) summary

cd04666
Location:18 → 137

Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
NM_153183.4 → NP_694853.1 diphosphoinositol polyphosphate phosphohydrolase 3-alpha

See identical proteins and their annotated locations for NP_694853.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC233976, AF469196, AK291952

Consensus CDS

CCDS35278.1

UniProtKB/Swiss-Prot

A8K7D7, D3DX69, Q86VK1, Q86VR0, Q8NFP7

UniProtKB/TrEMBL

B2RE29

Related

ENSP00000365174.3, ENST00000376006.7

Conserved Domains (1) summary

cd04666
Location:18 → 137

Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...