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    TTC31 tetratricopeptide repeat domain 31 [ Homo sapiens (human) ]

    Gene ID: 64427, updated on 10-Oct-2024

    Summary

    Official Symbol
    TTC31provided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 31provided by HGNC
    Primary source
    HGNC:HGNC:25759
    See related
    Ensembl:ENSG00000115282 AllianceGenome:HGNC:25759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in duodenum (RPKM 9.8), lymph node (RPKM 9.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TTC31 in Genome Data Viewer
    Location:
    2p13.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (74483081..74494559)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (74491645..74503123)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74710208..74721686)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16061 Neighboring gene mitochondrial ribosomal protein L53 Neighboring gene coiled-coil domain containing 142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16066 Neighboring gene ladybird homeobox 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74729628-74730252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74730253-74730878 Neighboring gene LBX2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74734085-74735015 Neighboring gene polycomb group ring finger 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 31
    Names
    TPR repeat protein 31

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376129.1NP_001363058.1  tetratricopeptide repeat protein 31 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (b).
      Source sequence(s)
      AC005041
      UniProtKB/TrEMBL
      Q86XF2
      Conserved Domains (2) summary
      PLN03088
      Location:342415
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:323351
      TPR; TPR repeat [structural motif]
    2. NM_001376130.1NP_001363059.1  tetratricopeptide repeat protein 31 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC005041
      UniProtKB/TrEMBL
      Q86XF2
      Conserved Domains (2) summary
      PLN03088
      Location:324397
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:305333
      TPR; TPR repeat [structural motif]
    3. NM_001376132.1NP_001363061.1  tetratricopeptide repeat protein 31 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC005041
      UniProtKB/TrEMBL
      Q86XF2
      Conserved Domains (2) summary
      PLN03088
      Location:322395
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:303331
      TPR; TPR repeat [structural motif]
    4. NM_001376133.1NP_001363062.1  tetratricopeptide repeat protein 31 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC005041
      UniProtKB/TrEMBL
      Q86XF2
      Conserved Domains (2) summary
      PLN03088
      Location:322395
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:303331
      TPR; TPR repeat [structural motif]
    5. NM_001376134.1NP_001363063.1  tetratricopeptide repeat protein 31 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC005041
      UniProtKB/TrEMBL
      Q86XF2
      Conserved Domains (2) summary
      PLN03088
      Location:253326
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:234262
      TPR; TPR repeat [structural motif]
    6. NM_001376135.1NP_001363064.1  tetratricopeptide repeat protein 31 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC005041
      UniProtKB/TrEMBL
      Q86XF2
      Conserved Domains (2) summary
      PLN03088
      Location:251324
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:232260
      TPR; TPR repeat [structural motif]
    7. NM_001376136.1NP_001363065.1  tetratricopeptide repeat protein 31 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC005041
      UniProtKB/TrEMBL
      G5E9H3
      Conserved Domains (2) summary
      PLN03088
      Location:324397
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:305333
      TPR; TPR repeat [structural motif]
    8. NM_001376137.1NP_001363066.1  tetratricopeptide repeat protein 31 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC005041
      UniProtKB/TrEMBL
      G5E9H3
      Conserved Domains (2) summary
      PLN03088
      Location:324397
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:305333
      TPR; TPR repeat [structural motif]
    9. NM_001376138.1NP_001363067.1  tetratricopeptide repeat protein 31 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC005041
      Conserved Domains (2) summary
      PLN03088
      Location:200273
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:181209
      TPR; TPR repeat [structural motif]
    10. NM_001376139.1NP_001363068.1  tetratricopeptide repeat protein 31 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC005041
      Conserved Domains (2) summary
      PLN03088
      Location:180253
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:161189
      TPR; TPR repeat [structural motif]
    11. NM_001376140.1NP_001363069.1  tetratricopeptide repeat protein 31 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC005041
      Conserved Domains (2) summary
      PLN03088
      Location:178251
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:159187
      TPR; TPR repeat [structural motif]
    12. NM_001376141.1NP_001363070.1  tetratricopeptide repeat protein 31 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC005041
      Conserved Domains (2) summary
      PLN03088
      Location:182255
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:163191
      TPR; TPR repeat [structural motif]
    13. NM_001376144.1NP_001363073.1  tetratricopeptide repeat protein 31 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC005041
      Conserved Domains (2) summary
      PLN03088
      Location:152225
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:133161
      TPR; TPR repeat [structural motif]
    14. NM_001376145.1NP_001363074.1  tetratricopeptide repeat protein 31 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC005041
      Conserved Domains (2) summary
      PLN03088
      Location:180244
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:161189
      TPR; TPR repeat [structural motif]
    15. NM_022492.6NP_071937.4  tetratricopeptide repeat protein 31 isoform a

      See identical proteins and their annotated locations for NP_071937.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC005041
      Consensus CDS
      CCDS42701.1
      UniProtKB/Swiss-Prot
      Q49AM3, Q4KN40, Q53FD4, Q9H9F7
      UniProtKB/TrEMBL
      Q86XF2
      Related
      ENSP00000233623.6, ENST00000233623.11
      Conserved Domains (2) summary
      PLN03088
      Location:324397
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:305333
      TPR; TPR repeat [structural motif]

    RNA

    1. NR_027749.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005041
      Related
      ENST00000424122.5
    2. NR_164770.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005041
    3. NR_164771.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005041
    4. NR_164772.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005041
    5. NR_164773.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005041
    6. NR_164774.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005041

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      74483081..74494559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533035.2XP_011531337.1  tetratricopeptide repeat protein 31 isoform X1

      UniProtKB/TrEMBL
      Q86XF2
      Conserved Domains (2) summary
      sd00006
      Location:325353
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:324390
      TPR_11; TPR repeat
    2. XM_047445421.1XP_047301377.1  tetratricopeptide repeat protein 31 isoform X6

    3. XM_047445422.1XP_047301378.1  tetratricopeptide repeat protein 31 isoform X7

    4. XM_047445423.1XP_047301379.1  tetratricopeptide repeat protein 31 isoform X8

      Related
      ENSP00000387213.1, ENST00000410003.5
    5. XM_047445424.1XP_047301380.1  tetratricopeptide repeat protein 31 isoform X9

      Related
      ENSP00000416823.3, ENST00000442235.6
    6. XM_047445419.1XP_047301375.1  tetratricopeptide repeat protein 31 isoform X4

    7. XM_047445417.1XP_047301373.1  tetratricopeptide repeat protein 31 isoform X2

    8. XM_047445418.1XP_047301374.1  tetratricopeptide repeat protein 31 isoform X3

    9. XM_047445420.1XP_047301376.1  tetratricopeptide repeat protein 31 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      74491645..74503123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343379.1XP_054199354.1  tetratricopeptide repeat protein 31 isoform X1

    2. XM_054343384.1XP_054199359.1  tetratricopeptide repeat protein 31 isoform X6

    3. XM_054343385.1XP_054199360.1  tetratricopeptide repeat protein 31 isoform X7

    4. XM_054343386.1XP_054199361.1  tetratricopeptide repeat protein 31 isoform X8

    5. XM_054343387.1XP_054199362.1  tetratricopeptide repeat protein 31 isoform X9

    6. XM_054343382.1XP_054199357.1  tetratricopeptide repeat protein 31 isoform X4

    7. XM_054343380.1XP_054199355.1  tetratricopeptide repeat protein 31 isoform X2

    8. XM_054343381.1XP_054199356.1  tetratricopeptide repeat protein 31 isoform X3

    9. XM_054343383.1XP_054199358.1  tetratricopeptide repeat protein 31 isoform X5