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    Clca4b chloride channel accessory 4B [ Mus musculus (house mouse) ]

    Gene ID: 99709, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Clca4bprovided by MGI
    Official Full Name
    chloride channel accessory 4Bprovided by MGI
    Primary source
    MGI:MGI:2139790
    See related
    Ensembl:ENSMUSG00000074195 AllianceGenome:MGI:2139790
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clca7
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be active in plasma membrane. Orthologous to human CLCA4 (chloride channel accessory 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 157.2), small intestine adult (RPKM 55.2) and 1 other tissue See more
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    Genomic context

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    See Clca4b in Genome Data Viewer
    Location:
    3 H2; 3 69.2 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144616682..144638290, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144910921..144932529, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57838 Neighboring gene chloride channel accessory 4C, pseudogene Neighboring gene STARR-seq mESC enhancer starr_09186 Neighboring gene chloride channel accessory 4A Neighboring gene predicted gene, 35066 Neighboring gene STARR-seq mESC enhancer starr_09188 Neighboring gene chloride channel accessory 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcium-activated chloride channel regulator 4
    Names
    calcium activated chloride channel
    chloride channel calcium activated 4B
    chloride channel calcium activated 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033199.3 → NP_001028371.1  calcium-activated chloride channel regulator 4 precursor

      See identical proteins and their annotated locations for NP_001028371.1

      Status: PROVISIONAL

      Source sequence(s)
      AK136515
      Consensus CDS
      CCDS38660.1
      UniProtKB/TrEMBL
      G3X8Z1, Q3UW98
      Related
      ENSMUSP00000096149.4, ENSMUST00000098549.4
      Conserved Domains (2) summary
      cd00198
      Location:307 → 459
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam08434
      Location:26 → 890
      CLCA; Calcium-activated chloride channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      144616682..144638290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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