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    Tmt1a thiol methyltransferase 1A1 [ Mus musculus (house mouse) ]

    Gene ID: 70152, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmt1aprovided by MGI
    Official Full Name
    thiol methyltransferase 1A1provided by MGI
    Primary source
    MGI:MGI:1916523
    See related
    Ensembl:ENSMUSG00000054619 AllianceGenome:MGI:1916523
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aam-B; UbiE1; Mettl7a; Mettl7a1; 2210414H16Rik; 3300001H21Rik
    Summary
    Predicted to enable mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Predicted to be involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Predicted to be located in endoplasmic reticulum and lipid droplet. Orthologous to human TMT1A (thiol methyltransferase 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 144.1), kidney adult (RPKM 109.2) and 14 other tissues See more
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    Genomic context

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    See Tmt1a in Genome Data Viewer
    Location:
    15 F1; 15 56.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100201969..100227882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100304145..100330001)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39747 Neighboring gene transmembrane (C-terminal) protease, serine 12 Neighboring gene predicted gene, 33666 Neighboring gene STARR-positive B cell enhancer ABC_E9423 Neighboring gene predicted gene, 53910 Neighboring gene thiol methyltransferase 1A3 Neighboring gene methyltransferase hypoxia inducible domain containing 1 Neighboring gene thiol methyltransferase 1A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LncRNA EPR-induced METTL7A1 modulates target gene translation. Briata P, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35748870, Free PMC Article
    2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA EPR-induced METTL7A1 modulates target gene translation.
      Title: LncRNA EPR-induced METTL7A1 modulates target gene translation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA m(6)A methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiol S-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lncRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    methyltransferase-like protein 7A
    Names
    methyltransferase like 7A
    methyltransferase like 7A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027334.3 → NP_081610.2  methyltransferase-like protein 7A

      See identical proteins and their annotated locations for NP_081610.2

      Status: PROVISIONAL

      Source sequence(s)
      AK076169
      Consensus CDS
      CCDS27833.1
      UniProtKB/TrEMBL
      Q5K4Q9, Q8C6B0
      Related
      ENSMUSP00000065271.4, ENSMUST00000067752.5
      Conserved Domains (2) summary
      COG0500
      Location:70 → 187
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08241
      Location:75 → 172
      Methyltransf_11; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100201969..100227882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521389.2 → XP_006521452.1  methyltransferase-like protein 7A isoform X1

      UniProtKB/TrEMBL
      Q5K4Q9
      Related
      ENSMUSP00000155621.2, ENSMUST00000230472.2
      Conserved Domains (1) summary
      pfam08241
      Location:57 → 154
      Methyltransf_11; Methyltransferase domain

    2. XM_006521390.5 → XP_006521453.1  methyltransferase-like protein 7A isoform X3

      UniProtKB/TrEMBL
      Q76I24
      Conserved Domains (1) summary
      pfam08241
      Location:30 → 127
      Methyltransf_11; Methyltransferase domain

    3. XM_011245728.2 → XP_011244030.1  methyltransferase-like protein 7A isoform X2

      See identical proteins and their annotated locations for XP_011244030.1

      UniProtKB/TrEMBL
      H3BJI7, Q9D7S5
      Related
      ENSMUSP00000155112.2, ENSMUST00000229588.2
      Conserved Domains (1) summary
      pfam08241
      Location:75 → 166
      Methyltransf_11; Methyltransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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