Sulf1 sulfatase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sulf1provided by MGI
Official Full Name: sulfatase 1provided by MGI
Primary source: MGI:MGI:2138563
See related: Ensembl:ENSMUSG00000016918 AllianceGenome:MGI:2138563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MSulf-1; mKIAA1077
Summary: Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including esophagus smooth muscle contraction; glomerular filtration; and skeletal system development. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb; lower urogenital tract; and sensory organ. Orthologous to human SULF1 (sulfatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 24.1), CNS E11.5 (RPKM 12.3) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A3; 1 3.35 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (12762421..12946090)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (12692197..12861192)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches.
Title: Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches.
Sulf-1 might play a critical role from development to maintenance of intervertebral disc homeostasis by regulating collagen expression
Title: Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis.
Loss of SULF1 expression is associated with corticospinal tract defect.
Title: Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.
Shh signaling requires the coordinated activity of Sulf1 and Sulf2 in order to reach that threshold in the mouse ventral spinal cord
Title: Sulfatase 2 Modulates Fate Change from Motor Neurons to Oligodendrocyte Precursor Cells through Coordinated Regulation of Shh Signaling with Sulfatase 1.
our findings show that Sulf-1 is an important tumor suppressor gene in hepatocellular carcinoma (HCC), and its over expression downregulates Msln and results in a decrease in HCC cell proliferation, migration, invasion, and lymphatic metastasis.
Title: Overexpression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
Sulf1 and Sulf2 play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation.
Title: Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling.
Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.
Title: Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.
Our study proposes a novel role of SULF1 in hepatocellular carcinoma tumor progression through augmentation of the TGF-beta pathway, thus defining SULF1 as a potential biomarker for tumor progression and a novel target for drug development for HCC.
Title: Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma.
It is proposed that Sulf1, Sulf2 and ErbB1 are involved in the inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system.
Title: Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro.
Sulf1/, but not Sulf2/, mice, exhibited a marked delay in healing of corneal epithelial wounds.
Title: The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit64 (e-PCR), detects polymorphism
- UniSTS:116247

Sulf1 (e-PCR), detects polymorphism
- UniSTS:498729

NoName (e-PCR)
- UniSTS:234071

AW121680 (e-PCR)
- UniSTS:178358

AI467640 (e-PCR)
- UniSTS:165065

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetylglucosamine-6-sulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosamine-6-sulfatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables N-acetylglucosamine-6-sulfatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables arylsulfatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables arylsulfatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables glycosaminoglycan binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in bone development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cartilage condensation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in chondrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in esophagus smooth muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in glomerular basement membrane development	IBA Inferred from Biological aspect of Ancestor more info
involved_in glomerular basement membrane development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glomerular filtration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heparan sulfate proteoglycan metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in innervation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in kidney development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in limb joint morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of prostatic bud formation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular endothelial growth factor production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial growth factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sulfur compound metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: extracellular sulfatase Sulf-1

Names: N-acetylglucosamine-6-sulfatase; arylsulfatase

NP_001185494.1

EC 3.1.6.1

EC 3.1.6.14

NP_001185495.1

EC 3.1.6.1

EC 3.1.6.14

NP_758498.1

EC 3.1.6.1

EC 3.1.6.14

XP_006495573.1

EC 3.1.6.1

EC 3.1.6.14

XP_006495575.1

EC 3.1.6.1

EC 3.1.6.14

XP_006495576.1

EC 3.1.6.1

EC 3.1.6.14

XP_036020584.1

EC 3.1.6.1

EC 3.1.6.14

XP_036020589.1

EC 3.1.6.1

EC 3.1.6.14

XP_036020591.1

EC 3.1.6.1

EC 3.1.6.14

XP_036020594.1

EC 3.1.6.1

EC 3.1.6.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198565.2 → NP_001185494.1 extracellular sulfatase Sulf-1 precursor

See identical proteins and their annotated locations for NP_001185494.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) may represent the longest transcript. All three variants encode the same protein.

Source sequence(s)

AC126044, AC134787, AC136316

Consensus CDS

CCDS14820.1

UniProtKB/Swiss-Prot

Q6ZPZ0, Q8BLJ0, Q8C1D3, Q8K007

UniProtKB/TrEMBL

A0A0R4J2D2

Related

ENSMUSP00000137523.2, ENSMUST00000177608.8

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 674

DUF3740; Sulfatase protein

cl23718
Location:767 → 816

ALP_like; alkaline phosphatases and sulfatases
NM_001198566.2 → NP_001185495.1 extracellular sulfatase Sulf-1 precursor

See identical proteins and their annotated locations for NP_001185495.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AC126044, AC134787, AC136316

Consensus CDS

CCDS14820.1

UniProtKB/Swiss-Prot

Q6ZPZ0, Q8BLJ0, Q8C1D3, Q8K007

UniProtKB/TrEMBL

A0A0R4J2D2

Related

ENSMUSP00000136014.2, ENSMUST00000180062.8

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 674

DUF3740; Sulfatase protein

cl23718
Location:767 → 816

ALP_like; alkaline phosphatases and sulfatases
NM_172294.2 → NP_758498.1 extracellular sulfatase Sulf-1 precursor

See identical proteins and their annotated locations for NP_758498.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AC126044, AC134787, AC136316

Consensus CDS

CCDS14820.1

UniProtKB/Swiss-Prot

Q6ZPZ0, Q8BLJ0, Q8C1D3, Q8K007

UniProtKB/TrEMBL

A0A0R4J2D2

Related

ENSMUSP00000085949.4, ENSMUST00000088585.10

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 674

DUF3740; Sulfatase protein

cl23718
Location:767 → 816

ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

12762421..12946090

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164698.1 → XP_036020591.1 extracellular sulfatase Sulf-1 isoform X3

UniProtKB/TrEMBL

A0A0R4J2D2

Related

ENSMUSP00000141153.2, ENSMUST00000186051.7

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 674

DUF3740; Sulfatase protein

cl23718
Location:767 → 816

ALP_like; alkaline phosphatases and sulfatases
XM_006495510.4 → XP_006495573.1 extracellular sulfatase Sulf-1 isoform X1

See identical proteins and their annotated locations for XP_006495573.1

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 674

DUF3740; Sulfatase protein

cl23718
Location:767 → 816

ALP_like; alkaline phosphatases and sulfatases
XM_036164696.1 → XP_036020589.1 extracellular sulfatase Sulf-1 isoform X2

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 674

DUF3740; Sulfatase protein

cl23718
Location:767 → 808

ALP_like; alkaline phosphatases and sulfatases
XM_006495513.5 → XP_006495576.1 extracellular sulfatase Sulf-1 isoform X1

See identical proteins and their annotated locations for XP_006495576.1

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 674

DUF3740; Sulfatase protein

cl23718
Location:767 → 816

ALP_like; alkaline phosphatases and sulfatases
XM_006495512.4 → XP_006495575.1 extracellular sulfatase Sulf-1 isoform X1

See identical proteins and their annotated locations for XP_006495575.1

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 674

DUF3740; Sulfatase protein

cl23718
Location:767 → 816

ALP_like; alkaline phosphatases and sulfatases
XM_036164691.1 → XP_036020584.1 extracellular sulfatase Sulf-1 isoform X1

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 674

DUF3740; Sulfatase protein

cl23718
Location:767 → 816

ALP_like; alkaline phosphatases and sulfatases
XM_036164701.1 → XP_036020594.1 extracellular sulfatase Sulf-1 isoform X4

UniProtKB/Swiss-Prot

Q6ZPZ0, Q8BLJ0, Q8C1D3, Q8K007

UniProtKB/TrEMBL

A0A0R4J2D2

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 674

DUF3740; Sulfatase protein

cl23718
Location:767 → 816

ALP_like; alkaline phosphatases and sulfatases