Krt18 keratin 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt18provided by MGI
Official Full Name: keratin 18provided by MGI
Primary source: MGI:MGI:96692
See related: Ensembl:ENSMUSG00000023043 AllianceGenome:MGI:96692
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K18; CK18; Krt1-18
Summary: Predicted to enable scaffold protein binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; and tumor necrosis factor-mediated signaling pathway. Located in cell periphery and keratin filament. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study hepatocellular carcinoma and metabolic dysfunction-associated steatohepatitis. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT18 (keratin 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 472.2), bladder adult (RPKM 233.5) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.22 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101936651..101940461)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102028216..102032026)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Skeletal muscle adaptations following eccentric contractions are not mediated by keratin 18.
Title: Skeletal muscle adaptations following eccentric contractions are not mediated by keratin 18.
KRT18 regulates trophoblast cell migration and invasion which are essential for embryo implantation.
Title: KRT18 regulates trophoblast cell migration and invasion which are essential for embryo implantation.
Keratin 8/18 Regulate the Akt Signaling Pathway.
Title: Keratin 8/18 Regulate the Akt Signaling Pathway.
Krt18 plays a complementary role to Krt19 in skeletal muscle in both assembling keratin-based filaments and transducing contractile force.
Title: Keratin 18 is an integral part of the intermediate filament network in murine skeletal muscle.
Cumulatively, these data indicate that altered CK14 (high) and CK18 (low) expression is perhaps an early event in bladder cancer tumorigenesis in females at least and is characteristic of both urothelial superficial pre-neoplastic and neoplastic lesions.
Title: Differential expression of cytokeratin 14 and 18 in bladder cancer tumorigenesis.
K18 deficiency of hepatocytes leads to steatosis, increasing with age, and finally to SH. K18 deficiency and age promote liver tumor development in mice, frequently on the basis of chromosomal instability, resembling human HCC with stemness features.
Title: Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis.
K8/K18-dependent PKCdelta- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 loss.
Title: Keratin impact on PKCδ- and ASMase-mediated regulation of hepatocyte lipid raft size - implication for FasR-associated apoptosis.
autoantibodies were detected in aging K18-null male mice that had a related liver phenotype but normal colon compared with K8-null mice, suggesting that the autoantibodies are linked to liver rather than colonic disease
Title: Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice.
In human failing myocardium, where TNF-alpha expression is upregulated, K8/K18 were also ectopically expressed
Title: Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18.
The findings demonstrate the near complete loss of K8/K18 with concomitant high levels of vimentin in CT26 cells, a chemically-induced mouse colonic tumor.
Title: Absence of keratins 8 and 18 in rodent epithelial cell lines associates with keratin gene mutation and DNA methylation: Cell line selective effects on cell invasion.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Krt2 (e-PCR), detects polymorphism
- UniSTS:143743

Krt2 (e-PCR), detects polymorphism
- UniSTS:143744

Krt18 (e-PCR), detects polymorphism
- UniSTS:525253

D15Mit40 (e-PCR), detects polymorphism
- UniSTS:116443

Krt18 (e-PCR), detects polymorphism
- UniSTS:499180

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in intermediate filament cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IDA Inferred from Direct Assay more info	PubMed
located_in keratin filament	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 18

Names: cytokeratin endo B; cytokeratin-18; keratin D; keratin complex 1, acidic, gene 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.