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    RALYL RALY RNA binding protein like [ Homo sapiens (human) ]

    Gene ID: 138046, updated on 3-Nov-2024

    Summary

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    Official Symbol
    RALYLprovided by HGNC
    Official Full Name
    RALY RNA binding protein likeprovided by HGNC
    Primary source
    HGNC:HGNC:27036
    See related
    Ensembl:ENSG00000184672 MIM:614648; AllianceGenome:HGNC:27036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPCL3
    Summary
    Enables identical protein binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 3.1), adrenal (RPKM 2.1) and 3 other tissues See more
    Orthologs
    mouse all
    NEW
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    Genomic context

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    See RALYL in Genome Data Viewer
    Location:
    8q21.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (84182787..84921844)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (84620396..85359723)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (85095022..85834079)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:84932099-84932600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:84932601-84933100 Neighboring gene tropomyosin alpha-3 chain-like Neighboring gene tropomyosin 3 pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:85202593-85203155 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:85336945-85337514 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:85532990-85533510 Neighboring gene Sharpr-MPRA regulatory region 11463 Neighboring gene RNA, U6 small nuclear 1040, pseudogene Neighboring gene PSMC2 pseudogene 2 Neighboring gene glucosamine-phosphate N-acetyltransferase 1 pseudogene Neighboring gene uncharacterized LOC124902092 Neighboring gene joining chain of multimeric IgA and IgM pseudogene 1 Neighboring gene ACTB pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel cDNA encodes a putative hRALY-like protein, hRALYL. Ji CN, et al. Mol Biol Rep, 2003 Mar. PMID 12688537
    2. Over-expression of RALYL suppresses the progression of ovarian clear cell carcinoma through inhibiting MAPK and CDH1 signaling pathways. Xia Y, et al. Int J Med Sci, 2021. PMID 33437214, Free PMC Article
    3. Exploring the role of RALYL in Alzheimer's disease reserve by network-based approaches. Zhang Y, et al. Alzheimers Res Ther, 2020 Dec 9. PMID 33298176, Free PMC Article
    4. Screening of LRRK2 interactants by yeast 2-hybrid analysis. Zheng XY, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2008 Oct. PMID 19001729
    5. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. Cobb J, et al. Pharmacogenomics J, 2014 Aug. PMID 24709693, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Over-expression of RALYL suppresses the progression of ovarian clear cell carcinoma through inhibiting MAPK and CDH1 signaling pathways.
      Title: Over-expression of RALYL suppresses the progression of ovarian clear cell carcinoma through inhibiting MAPK and CDH1 signaling pathways.
    2. Exploring the role of RALYL in Alzheimer's disease reserve by network-based approaches.
      Title: Exploring the role of RALYL in Alzheimer's disease reserve by network-based approaches.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding Raly-like protein
    Names
    heterogeneous nuclear ribonucleoprotein C-like 3
    hnRNP core protein C-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100391.3 → NP_001093861.1  RNA-binding Raly-like protein isoform 1

      See identical proteins and their annotated locations for NP_001093861.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS55252.1
      UniProtKB/TrEMBL
      B3KSX3
      Related
      ENSP00000430128.1, ENST00000517638.5
      Conserved Domains (2) summary
      pfam10779
      Location:212 → 257
      XhlA; Haemolysin XhlA
      cl17169
      Location:28 → 110
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001100392.3 → NP_001093862.1  RNA-binding Raly-like protein isoform 2

      See identical proteins and their annotated locations for NP_001093862.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 through 4 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      Consensus CDS
      CCDS55253.1
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2
      UniProtKB/TrEMBL
      B3KSX3
      Related
      ENSP00000430394.1, ENST00000522455.5
      Conserved Domains (2) summary
      pfam10779
      Location:199 → 244
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001100393.3 → NP_001093863.1  RNA-binding Raly-like protein isoform 2

      See identical proteins and their annotated locations for NP_001093863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 through 4 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS55253.1
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2
      UniProtKB/TrEMBL
      B3KSX3
      Related
      ENSP00000428667.1, ENST00000521695.5
      Conserved Domains (2) summary
      pfam10779
      Location:199 → 244
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001287243.3 → NP_001274172.1  RNA-binding Raly-like protein isoform 3

      See identical proteins and their annotated locations for NP_001274172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and the 5' coding region, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS75760.1
      UniProtKB/TrEMBL
      B3KSX3, B3KT61
      Related
      ENSP00000430065.1, ENST00000518566.5
      Conserved Domains (3) summary
      COG0724
      Location:12 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam10779
      Location:188 → 233
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001287244.2 → NP_001274173.1  RNA-binding Raly-like protein isoform 4

      See identical proteins and their annotated locations for NP_001274173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate 5' terminal exon resulting in a novel 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC009901, AC087368
      Consensus CDS
      CCDS75761.1
      UniProtKB/Swiss-Prot
      Q86SE5
      Related
      ENSP00000428807.1, ENST00000523850.5
      Conserved Domains (1) summary
      pfam10779
      Location:126 → 171
      XhlA; Haemolysin XhlA

    6. NM_001354305.2 → NP_001341234.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      Consensus CDS
      CCDS55253.1
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (2) summary
      pfam10779
      Location:199 → 244
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. NM_001354306.2 → NP_001341235.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS55253.1
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (2) summary
      pfam10779
      Location:199 → 244
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. NM_001354307.2 → NP_001341236.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS75760.1
      UniProtKB/TrEMBL
      B3KSX3, B3KT61
      Conserved Domains (3) summary
      COG0724
      Location:12 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam10779
      Location:188 → 233
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. NM_001354308.2 → NP_001341237.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC027043, AC087368, AC092699
      Consensus CDS
      CCDS55253.1
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (2) summary
      pfam10779
      Location:199 → 244
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. NM_001354309.2 → NP_001341238.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS75760.1
      UniProtKB/TrEMBL
      B3KSX3, B3KT61
      Conserved Domains (3) summary
      COG0724
      Location:12 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam10779
      Location:188 → 233
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. NM_001354310.2 → NP_001341239.1  RNA-binding Raly-like protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC087368
      Conserved Domains (1) summary
      pfam10779
      Location:111 → 156
      XhlA; Haemolysin XhlA

    12. NM_001354311.2 → NP_001341240.1  RNA-binding Raly-like protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (1) summary
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    13. NM_001354312.2 → NP_001341241.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      Consensus CDS
      CCDS75760.1
      UniProtKB/TrEMBL
      B3KSX3, B3KT61
      Conserved Domains (3) summary
      COG0724
      Location:12 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam10779
      Location:188 → 233
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    14. NM_001354313.2 → NP_001341242.1  RNA-binding Raly-like protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (1) summary
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    15. NM_001354314.2 → NP_001341243.1  RNA-binding Raly-like protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (2) summary
      COG1579
      Location:195 → 250
      COG1579; Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only]
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    16. NM_001354315.2 → NP_001341244.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS75760.1
      UniProtKB/TrEMBL
      B3KSX3, B3KT61
      Conserved Domains (3) summary
      COG0724
      Location:12 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam10779
      Location:188 → 233
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    17. NM_001354316.2 → NP_001341245.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      Consensus CDS
      CCDS55253.1
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (2) summary
      pfam10779
      Location:199 → 244
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    18. NM_001354317.2 → NP_001341246.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      Consensus CDS
      CCDS75760.1
      UniProtKB/TrEMBL
      B3KSX3, B3KT61
      Conserved Domains (3) summary
      COG0724
      Location:12 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam10779
      Location:188 → 233
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    19. NM_001354318.2 → NP_001341247.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS75760.1
      UniProtKB/TrEMBL
      B3KSX3, B3KT61
      Conserved Domains (3) summary
      COG0724
      Location:12 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam10779
      Location:188 → 233
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    20. NM_001354319.2 → NP_001341248.1  RNA-binding Raly-like protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (1) summary
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    21. NM_001354320.2 → NP_001341249.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS55253.1
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (2) summary
      pfam10779
      Location:199 → 244
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    22. NM_001354321.2 → NP_001341250.1  RNA-binding Raly-like protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (3) summary
      COG0724
      Location:25 → 203
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam10779
      Location:201 → 246
      XhlA; Haemolysin XhlA
      cl17169
      Location:28 → 110
      RRM_SF; RNA recognition motif (RRM) superfamily

    23. NM_001354322.2 → NP_001341251.1  RNA-binding Raly-like protein isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Conserved Domains (2) summary
      COG0724
      Location:25 → 203
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:28 → 110
      RRM_SF; RNA recognition motif (RRM) superfamily

    24. NM_001354323.2 → NP_001341252.1  RNA-binding Raly-like protein isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (1) summary
      cl17169
      Location:28 → 110
      RRM_SF; RNA recognition motif (RRM) superfamily

    25. NM_001354325.2 → NP_001341254.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS55253.1
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2
      UniProtKB/TrEMBL
      B3KSX3
      Conserved Domains (2) summary
      pfam10779
      Location:199 → 244
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    26. NM_001413300.1 → NP_001400229.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/TrEMBL
      B3KT61

    27. NM_001413301.1 → NP_001400230.1  RNA-binding Raly-like protein isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816

    28. NM_001413302.1 → NP_001400231.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      UniProtKB/TrEMBL
      B3KT61

    29. NM_001413303.1 → NP_001400232.1  RNA-binding Raly-like protein isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368

    30. NM_001413304.1 → NP_001400233.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2

    31. NM_001413305.1 → NP_001400234.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2

    32. NM_001413306.1 → NP_001400235.1  RNA-binding Raly-like protein isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368

    33. NM_001413307.1 → NP_001400236.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      UniProtKB/TrEMBL
      B3KT61

    34. NM_001413308.1 → NP_001400237.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2

    35. NM_001413309.1 → NP_001400238.1  RNA-binding Raly-like protein isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368

    36. NM_001413310.1 → NP_001400239.1  RNA-binding Raly-like protein isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368

    37. NM_001413311.1 → NP_001400240.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2

    38. NM_001413312.1 → NP_001400241.1  RNA-binding Raly-like protein isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368

    39. NM_001413313.1 → NP_001400242.1  RNA-binding Raly-like protein isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368

    40. NM_001413314.1 → NP_001400243.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2

    41. NM_001413315.1 → NP_001400244.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/TrEMBL
      B3KT61

    42. NM_001413316.1 → NP_001400245.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2

    43. NM_001413318.1 → NP_001400247.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2

    44. NM_001413319.1 → NP_001400248.1  RNA-binding Raly-like protein isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368

    45. NM_001413320.1 → NP_001400249.1  RNA-binding Raly-like protein isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368

    46. NM_001413321.1 → NP_001400250.1  RNA-binding Raly-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2

    47. NM_001413322.1 → NP_001400251.1  RNA-binding Raly-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      UniProtKB/TrEMBL
      B3KT61

    48. NM_001413323.1 → NP_001400252.1  RNA-binding Raly-like protein isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368, AC103816

    49. NM_001413324.1 → NP_001400253.1  RNA-binding Raly-like protein isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC087368
      Related
      ENSP00000428310.1, ENST00000521376.1

    50. NM_001413329.1 → NP_001400258.1  RNA-binding Raly-like protein isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC009901, AC087368

    51. NM_173848.7 → NP_776247.3  RNA-binding Raly-like protein isoform 2

      See identical proteins and their annotated locations for NP_776247.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 through 4 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC009901, AC012400, AC027043, AC087368
      Consensus CDS
      CCDS55253.1
      UniProtKB/Swiss-Prot
      B3KTH2, G3V129, Q6ZW87, Q86SE5, Q8N1C2
      UniProtKB/TrEMBL
      B3KSX3
      Related
      ENSP00000430367.1, ENST00000521268.6
      Conserved Domains (2) summary
      pfam10779
      Location:199 → 244
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      84182787..84921844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447066.2 → XP_024302834.1  RNA-binding Raly-like protein isoform X1

      UniProtKB/TrEMBL
      B3KSX3, B3KT61
      Conserved Domains (3) summary
      COG0724
      Location:12 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam10779
      Location:188 → 233
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_047421387.1 → XP_047277343.1  RNA-binding Raly-like protein isoform X4

    3. XM_024447070.2 → XP_024302838.1  RNA-binding Raly-like protein isoform X6

      Conserved Domains (1) summary
      pfam04111
      Location:90 → 146
      APG6; Autophagy protein Apg6

    4. XM_011517462.4 → XP_011515764.1  RNA-binding Raly-like protein isoform X3

      Conserved Domains (2) summary
      COG0724
      Location:12 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:20 → 88
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_024447069.2 → XP_024302837.1  RNA-binding Raly-like protein isoform X5

      Conserved Domains (1) summary
      pfam04111
      Location:98 → 154
      APG6; Autophagy protein Apg6

    6. XM_024447068.2 → XP_024302836.1  RNA-binding Raly-like protein isoform X2

      Conserved Domains (2) summary
      COG0724
      Location:25 → 203
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12605
      Location:33 → 101
      RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)

    7. XM_024447065.2 → XP_024302833.1  RNA-binding Raly-like protein isoform X1

      UniProtKB/TrEMBL
      B3KSX3, B3KT61
      Conserved Domains (3) summary
      COG0724
      Location:12 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam10779
      Location:188 → 233
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      84620396..85359723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359791.1 → XP_054215766.1  RNA-binding Raly-like protein isoform X1

      UniProtKB/TrEMBL
      B3KT61

    2. XM_054359794.1 → XP_054215769.1  RNA-binding Raly-like protein isoform X4

    3. XM_054359796.1 → XP_054215771.1  RNA-binding Raly-like protein isoform X6

    4. XM_054359793.1 → XP_054215768.1  RNA-binding Raly-like protein isoform X3

    5. XM_054359795.1 → XP_054215770.1  RNA-binding Raly-like protein isoform X5

    6. XM_054359792.1 → XP_054215767.1  RNA-binding Raly-like protein isoform X2

    7. XM_054359790.1 → XP_054215765.1  RNA-binding Raly-like protein isoform X1

      UniProtKB/TrEMBL
      B3KT61
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86SE5.2 GenPept UniProtKB/Swiss-Prot:Q86SE5

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