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    IVNS1ABP influenza virus NS1A binding protein [ Homo sapiens (human) ]

    Gene ID: 10625, updated on 3-Nov-2024

    Summary

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    Official Symbol
    IVNS1ABPprovided by HGNC
    Official Full Name
    influenza virus NS1A binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16951
    See related
    Ensembl:ENSG00000116679 MIM:609209; AllianceGenome:HGNC:16951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ND1; ARA3; NS-1; IMD70; NS1BP; FLARA3; KLHL39; NS1-BP; HSPC068
    Summary
    Involved in RNA splicing; negative regulation of protein ubiquitination; and response to virus. Located in cytosol. Implicated in immunodeficiency 70. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 56.1), kidney (RPKM 31.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IVNS1ABP in Genome Data Viewer
    Location:
    1q25.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (185296388..185317243, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (184653292..184680201, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (185265520..185286375, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene ribosomal protein L5 pseudogene 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:185226026-185226636 Neighboring gene uncharacterized LOC105371651 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:185285701-185286314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2243 Neighboring gene microtubule associated protein 1 light chain 3 beta pseudogene Neighboring gene CBS mRNA stabilizing lncRNA Neighboring gene Sharpr-MPRA regulatory region 834 Neighboring gene RNA, U7 small nuclear 183 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. Wolff T, et al. J Virol, 1998 Sep. PMID 9696811, Free PMC Article
    2. Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Zhang K, et al. Proc Natl Acad Sci U S A, 2018 Dec 26. PMID 30538201, Free PMC Article
    3. Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 Å resolution. Guo L, et al. Acta Crystallogr F Struct Biol Commun, 2018 Mar 1. PMID 29497022, Free PMC Article
    4. Soluble NS1 Antagonizes IgG- and IgA- Mediated Monocytic Phagocytosis of DENV Infected Cells. Waldran MJ, et al. J Infect Dis, 2023 Jun 28. PMID 37103221
    5. Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing. Thompson MG, et al. Nat Commun, 2018 Jun 19. PMID 29921878, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Soluble NS1 Antagonizes IgG- and IgA- Mediated Monocytic Phagocytosis of DENV Infected Cells.
      Title: Soluble NS1 Antagonizes IgG- and IgA- Mediated Monocytic Phagocytosis of DENV Infected Cells.
    2. The central BACK domain of NS1-BP interacts directly with splicing factors such as hnRNP K and PTBP1 and with the viral NS1 protein.
      Title: Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
    3. In esophageal squamous cell carcinoma (ESCC) tissues, c-Myc expression was inversely correlated with NS1-binding protein (NS1-BP) levels, and was associated with a shorter disease-specific survival (DSS).
      Title: NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc.
    4. Comparison of the Kelch-domain structures of NS1-BP and its homologues showed that the Gly-Gly pair in beta-strand B and the hydrophobic Trp residue in beta-strand D are highly conserved, while the B-C loops in blades 2 and 6 are variable
      Title: Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 Å resolution.
    5. Data show that heterogeneous nuclear ribonucleoprotein K (hnRNP K) and influenza virus NS1A binding protein (NS1-BP) regulate host splicing events and that viral infection causes mis-splicing of some of these transcripts.
      Title: Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.
    6. Our study identifies KLHL39 as a negative regulator of Cul3-KLHL20 ubiquitin ligase and reveals a role of KLHL39-mediated PML and DAPK stabilization in colon cancer metastasis.
      Title: KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.
    7. NS1-BP-hnRNPK complex is a key mediator of influenza A virus gene expression.
      Title: Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.
    8. This study provided evidence that miRNA-548an is involved in the regulation of NS1ABP.
      Title: Expression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virus.
    9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Immunodeficiency 70
    MedGen: C5436501 OMIM: 618969 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with influenza virus NS1A binding protein (IVNS1ABP; NS1BP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10069, FLJ10411, FLJ10962, FLJ35593, FLJ36593, KIAA0850, DKFZp686K06216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of transcription regulator complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    influenza virus NS1A-binding protein
    Names
    NCX downstream gene 1
    NS1-binding protein
    aryl hydrocarbon receptor-associated 3
    aryl hydrocarbon receptor-associated protein 3
    kelch-like family member 39
    kelch-like protein 39

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006469.5 → NP_006460.2  influenza virus NS1A-binding protein

      See identical proteins and their annotated locations for NP_006460.2

      Status: VALIDATED

      Source sequence(s)
      AB020657, AF205218, AK000931, AL137640
      Consensus CDS
      CCDS1368.1
      UniProtKB/Swiss-Prot
      A8K8R6, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480, Q9Y6Y0
      Related
      ENSP00000356468.3, ENST00000367498.8
      Conserved Domains (4) summary
      PHA03098
      Location:23 → 638
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:502 → 545
      Kelch; KELCH repeat [structural motif]
      cd18306
      Location:14 → 137
      BTB_POZ_NS1BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP)
      cd18502
      Location:129 → 225
      BACK_NS1BP_IVNS1ABP; BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      185296388..185317243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434096.1 → XP_047290052.1  influenza virus NS1A-binding protein isoform X2

    2. XM_047434070.1 → XP_047290026.1  influenza virus NS1A-binding protein isoform X1

      UniProtKB/Swiss-Prot
      A8K8R6, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480, Q9Y6Y0

    3. XM_047434109.1 → XP_047290065.1  influenza virus NS1A-binding protein isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      184653292..184680201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333888.1 → XP_054189863.1  influenza virus NS1A-binding protein isoform X1

      UniProtKB/Swiss-Prot
      A8K8R6, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480, Q9Y6Y0

    2. XM_054333889.1 → XP_054189864.1  influenza virus NS1A-binding protein isoform X2

    3. XM_054333890.1 → XP_054189865.1  influenza virus NS1A-binding protein isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016389.2: Suppressed sequence

      Description
      NM_016389.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6Y0.3 GenPept UniProtKB/Swiss-Prot:Q9Y6Y0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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