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    FRK fyn related Src family tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 2444, updated on 14-Nov-2024

    Summary

    Official Symbol
    FRKprovided by HGNC
    Official Full Name
    fyn related Src family tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:3955
    See related
    Ensembl:ENSG00000111816 MIM:606573; AllianceGenome:HGNC:3955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GTK; RAK; PTK5
    Summary
    The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 3.0), duodenum (RPKM 2.8) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FRK in Genome Data Viewer
    Location:
    6q22.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (115931149..116100725, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (117114676..117284719, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (116252312..116382054, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:116049821-116050322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:116210349-116211066 Neighboring gene uncharacterized LOC124901385 Neighboring gene NANOG hESC enhancer GRCh37_chr6:116235207-116235708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24978 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88040 Neighboring gene triosephosphate isomerase 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24979 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:116412309-116412554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:116421676-116422198 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:116422199-116422719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24980 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88050 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88070 Neighboring gene Sharpr-MPRA regulatory region 2872 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88113 Neighboring gene 5'-nucleotidase domain containing 1 Neighboring gene MPRA-validated peak6050 silencer Neighboring gene collagen type X alpha 1 chain Neighboring gene NIP7 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24981 Neighboring gene TSPY like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase FRK
    Names
    PTK5 protein tyrosine kinase 5
    fyn-related kinase
    nuclear tyrosine protein kinase RAK
    protein-tyrosine kinase 5
    NP_002022.1
    XP_005266937.1
    XP_005266938.1
    XP_011533956.1
    XP_011533957.1
    XP_011533958.1
    XP_016866134.1
    XP_047274510.1
    XP_047274511.1
    XP_054210960.1
    XP_054210961.1
    XP_054210962.1
    XP_054210963.1
    XP_054210964.1
    XP_054210965.1
    XP_054210966.1
    XP_054210967.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002031.3NP_002022.1  tyrosine-protein kinase FRK

      See identical proteins and their annotated locations for NP_002022.1

      Status: REVIEWED

      Source sequence(s)
      AL021451, AL121963, AL357141
      Consensus CDS
      CCDS5103.1
      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
      UniProtKB/TrEMBL
      B2R8C2
      Related
      ENSP00000476145.1, ENST00000606080.2
      Conserved Domains (3) summary
      cd10369
      Location:112207
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:47104
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:225494
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      115931149..116100725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535656.3XP_011533958.1  tyrosine-protein kinase FRK isoform X2

      Conserved Domains (3) summary
      cd05068
      Location:112381
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
      pfam07714
      Location:121374
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:394
      SH2; Src homology 2 (SH2) domain
    2. XM_011535655.3XP_011533957.1  tyrosine-protein kinase FRK isoform X1

      See identical proteins and their annotated locations for XP_011533957.1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
      UniProtKB/TrEMBL
      B2R8C2
      Conserved Domains (3) summary
      cd10369
      Location:112207
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:47104
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:225494
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
    3. XM_011535654.3XP_011533956.1  tyrosine-protein kinase FRK isoform X1

      See identical proteins and their annotated locations for XP_011533956.1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
      UniProtKB/TrEMBL
      B2R8C2
      Conserved Domains (3) summary
      cd10369
      Location:112207
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:47104
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:225494
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
    4. XM_047418554.1XP_047274510.1  tyrosine-protein kinase FRK isoform X1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
    5. XM_047418555.1XP_047274511.1  tyrosine-protein kinase FRK isoform X1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
    6. XM_017010645.2XP_016866134.1  tyrosine-protein kinase FRK isoform X1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
      UniProtKB/TrEMBL
      B2R8C2
      Conserved Domains (3) summary
      cd10369
      Location:112207
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:47104
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:225494
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
    7. XM_005266880.5XP_005266937.1  tyrosine-protein kinase FRK isoform X1

      See identical proteins and their annotated locations for XP_005266937.1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
      UniProtKB/TrEMBL
      B2R8C2
      Conserved Domains (3) summary
      cd10369
      Location:112207
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:47104
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:225494
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
    8. XM_005266881.3XP_005266938.1  tyrosine-protein kinase FRK isoform X1

      See identical proteins and their annotated locations for XP_005266938.1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
      UniProtKB/TrEMBL
      B2R8C2
      Conserved Domains (3) summary
      cd10369
      Location:112207
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:47104
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:225494
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      117114676..117284719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354992.1XP_054210967.1  tyrosine-protein kinase FRK isoform X2

    2. XM_054354990.1XP_054210965.1  tyrosine-protein kinase FRK isoform X1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
    3. XM_054354991.1XP_054210966.1  tyrosine-protein kinase FRK isoform X1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
    4. XM_054354986.1XP_054210961.1  tyrosine-protein kinase FRK isoform X1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
    5. XM_054354989.1XP_054210964.1  tyrosine-protein kinase FRK isoform X1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
    6. XM_054354987.1XP_054210962.1  tyrosine-protein kinase FRK isoform X1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
    7. XM_054354985.1XP_054210960.1  tyrosine-protein kinase FRK isoform X1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5
    8. XM_054354988.1XP_054210963.1  tyrosine-protein kinase FRK isoform X1

      UniProtKB/Swiss-Prot
      B4DY49, P42685, Q13128, Q9NTR5