PSMG3 proteasome assembly chaperone 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PSMG3provided by HGNC
Official Full Name: proteasome assembly chaperone 3provided by HGNC
Primary source: HGNC:HGNC:22420
See related: Ensembl:ENSG00000157778 MIM:617528; AllianceGenome:HGNC:22420
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAC3; Pba3; C7orf48
Summary: Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bone marrow (RPKM 8.7), skin (RPKM 6.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p22.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (1567332..1570032, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (1679436..1682138, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (1606968..1609668, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anaplasma phagocytophilum AptA enhances the UPS, autophagy, and anti-apoptosis of host cells by PSMG3.
Title: Anaplasma phagocytophilum AptA enhances the UPS, autophagy, and anti-apoptosis of host cells by PSMG3.
we report the identification of a chaperone, designated PAC3, as a component of alpha rings. PAC3 dissociates before the formation of half-proteasomes, a process coupled with the recruitment of beta subunits and hUmp1.[PAC3]
Title: Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: proteasome assembly chaperone 3

Names: PAC-3; hPAC3; proteasome (prosome, macropain) assembly chaperone 3; proteasome assembling chaperone 3; proteasome chaperone homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134340.2 → NP_001127812.1 proteasome assembly chaperone 3

See identical proteins and their annotated locations for NP_001127812.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

BM825255, CN261807

Consensus CDS

CCDS5327.1

UniProtKB/Swiss-Prot

A4D216, A8MPW2, Q9BT73

Related

ENSP00000384799.3, ENST00000404674.7

Conserved Domains (1) summary

pfam10178
Location:34 → 119

PAC3; Proteasome assembly chaperone 3
NM_032302.4 → NP_115678.1 proteasome assembly chaperone 3

See identical proteins and their annotated locations for NP_115678.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC093734, BC027171, CN261807

Consensus CDS

CCDS5327.1

UniProtKB/Swiss-Prot

A4D216, A8MPW2, Q9BT73

Related

ENSP00000288607.2, ENST00000288607.3

Conserved Domains (1) summary

pfam10178
Location:34 → 119

PAC3; Proteasome assembly chaperone 3