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    LINC00482 long intergenic non-protein coding RNA 482 [ Homo sapiens (human) ]

    Gene ID: 284185, updated on 17-Sep-2024

    Summary

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    Official Symbol
    LINC00482provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 482provided by HGNC
    Primary source
    HGNC:HGNC:26816
    See related
    AllianceGenome:HGNC:26816
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C17orf55
    Expression
    Broad expression in spleen (RPKM 1.2), colon (RPKM 0.7) and 17 other tissues See more
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    Genomic context

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    See LINC00482 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81302824..81309248, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82214722..82221494, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79276624..79283048, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12959 Neighboring gene solute carrier family 38 member 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79225481-79226148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79228507-79229198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79255689-79256202 Neighboring gene Sharpr-MPRA regulatory region 13761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12961 Neighboring gene uncharacterized LOC124904082 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79273333-79273505 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79291988-79292526 Neighboring gene TMEM105 long non-coding RNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79302243-79302814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79302815-79303386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79303387-79303956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79305100-79305670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79305671-79306241 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79313044-79313992 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79319562-79319850 Neighboring gene regulator of early neurogenesis 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Extracellular vesicle-derived LINC00482 induces microglial M2 polarization to facilitate brain metastasis of NSCLC. Xu W, et al. Cancer Lett, 2023 May 1. PMID 36963460
    2. Silencing LINC00482 inhibits tumor-associated inflammation and angiogenesis through down-regulation of MMP-15 via FOXA1 in bladder cancer. Wang Y, et al. Aging (Albany NY), 2020 Dec 11. PMID 33323547, Free PMC Article
    3. Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis. Huang W, et al. Int J Chron Obstruct Pulmon Dis, 2024. PMID 38348310, Free PMC Article
    4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis.
      Title: Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis.
    2. Extracellular vesicle-derived LINC00482 induces microglial M2 polarization to facilitate brain metastasis of NSCLC.
      Title: Extracellular vesicle-derived LINC00482 induces microglial M2 polarization to facilitate brain metastasis of NSCLC.
    3. Silencing LINC00482 inhibits tumor-associated inflammation and angiogenesis through down-regulation of MMP-15 via FOXA1 in bladder cancer.
      Title: Silencing LINC00482 inhibits tumor-associated inflammation and angiogenesis through down-regulation of MMP-15 via FOXA1 in bladder cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • FLJ39421, MGC120553, MGC120556

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038080.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC027601, AK096740

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81302824..81309248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82214722..82221494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178519.2: Suppressed sequence

      Description
      NM_178519.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N8I6.1 GenPept UniProtKB/Swiss-Prot:Q8N8I6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials