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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_013012.1Â RefSeqGene
- Range
-
5003..127412
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001165946.2 → NP_001159418.1  insulin-degrading enzyme isoform 2
See identical proteins and their annotated locations for NP_001159418.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks multiple exons that are present in the 5' end of variant 1. Variant 2 contains a novel exon at its 5' end and begins translation from a downstream in-frame start codon, compared to variant 1. The encoded protein (isoform 2) lacks 555 amino acids from the N-terminus of isoform 1 but is identical to its C-terminal 464 amino acids. Compared to isoform 1, isoform 2 lacks two of three M16 peptidase domains and the N-terminal catalytic domain. The C-terminus of isoform 2 retains the oligomerization domain and peroxisomal targeting sequence present in isoform 1.
- Source sequence(s)
-
AK316407, AL356128, BX648462, CF780766, CK824565, DA879845, DB445060
- Consensus CDS
-
CCDS53554.1
- UniProtKB/TrEMBL
-
B7Z7W6
- Related
- ENSP00000360637.5, ENST00000371581.9
- Conserved Domains (1) summary
-
- cl25708
Location:2 → 403
- Peptidase_M16; Insulinase (Peptidase family M16)
-
NM_001322793.2 → NP_001309722.1  insulin-degrading enzyme isoform 3
Status: REVIEWED
- Source sequence(s)
-
AL356128
- Consensus CDS
-
CCDS91301.1
- UniProtKB/TrEMBL
- A0A3B3ISG5, A0A7I2V3E3
- Related
- ENSP00000497272.1, ENST00000650060.2
- Conserved Domains (4) summary
-
- COG1025
Location:52 → 958
- Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
- pfam00675
Location:74 → 212
- Peptidase_M16; Insulinase (Peptidase family M16)
- pfam05193
Location:238 → 416
- Peptidase_M16_C; Peptidase M16 inactive domain
- pfam16187
Location:422 → 703
- Peptidase_M16_M; Middle or third domain of peptidase_M16
-
NM_001322794.2 → NP_001309723.1  insulin-degrading enzyme isoform 4
Status: REVIEWED
- Source sequence(s)
-
AL356128
- UniProtKB/TrEMBL
-
A0A7I2V3E3
- Conserved Domains (4) summary
-
- COG1025
Location:52 → 919
- Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
- pfam00675
Location:74 → 212
- Peptidase_M16; Insulinase (Peptidase family M16)
- pfam05193
Location:218 → 377
- Peptidase_M16_C; Peptidase M16 inactive domain
- pfam16187
Location:383 → 664
- Peptidase_M16_M; Middle or third domain of peptidase_M16
-
NM_001322795.2 → NP_001309724.1  insulin-degrading enzyme isoform 5
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) and variant 6 both encode isoform 5.
- Source sequence(s)
-
AL356128
- UniProtKB/TrEMBL
-
A0A7I2V3E3
- Conserved Domains (1) summary
-
- COG1025
Location:11 → 917
- Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
-
NM_001322796.1 → NP_001309725.1  insulin-degrading enzyme isoform 5
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) and variant 5 both encode isoform (5).
- Source sequence(s)
-
AL356128, BX648462
- UniProtKB/TrEMBL
-
A0A7I2V3E3
- Conserved Domains (1) summary
-
- COG1025
Location:11 → 917
- Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
-
NM_001322797.2 → NP_001309726.1  insulin-degrading enzyme isoform 6
Status: REVIEWED
- Source sequence(s)
-
AK093287, AL356128
- Consensus CDS
-
CCDS91299.1
- UniProtKB/TrEMBL
- B3KSB8, B7Z7W6
- Related
- ENSP00000504053.1, ENST00000496903.5
- Conserved Domains (2) summary
-
- pfam05193
Location:151 → 334
- Peptidase_M16_C; Peptidase M16 inactive domain
- pfam16187
Location:1 → 148
- Peptidase_M16_M; Middle or third domain of peptidase_M16
-
NM_001410974.1 → NP_001397903.1  insulin-degrading enzyme isoform 7
Status: REVIEWED
- Source sequence(s)
-
AL356128
- Consensus CDS
-
CCDS91300.1
- UniProtKB/TrEMBL
-
A0A7I2V2P6
- Related
- ENSP00000503025.1, ENST00000678715.1
-
NM_004969.4 → NP_004960.2  insulin-degrading enzyme isoform 1
See identical proteins and their annotated locations for NP_004960.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Alternative translation initiation of this transcript variant produces an isoform that lacks 41 aa from the N-terminus and, purportedly, lacks an N-terminal mitochondrial targeting sequence.
- Source sequence(s)
-
BC096337, BX648462, CF780766, CK824565, DA879845, DB219527
- Consensus CDS
-
CCDS7421.1
- UniProtKB/Swiss-Prot
- B2R721, B7ZAU2, D3DR35, P14735, Q5T5N2
- UniProtKB/TrEMBL
-
A0A7I2V3E3
- Related
- ENSP00000265986.6, ENST00000265986.11
- Conserved Domains (1) summary
-
- COG1025
Location:52 → 958
- Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
RNA
-
NR_136399.2 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AL356128
- Related
-
ENST00000678844.1
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000010.11Â Reference GRCh38.p14 Primary Assembly
- Range
-
92451684..92574093 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047425171.1 → XP_047281127.1  insulin-degrading enzyme isoform X3
-
XM_017016190.2 → XP_016871679.2  insulin-degrading enzyme isoform X2
-
XM_047425169.1 → XP_047281125.1  insulin-degrading enzyme isoform X1
-
XM_017016188.2 → XP_016871677.1  insulin-degrading enzyme isoform X3
- UniProtKB/TrEMBL
-
A0A7I2V3E3
- Conserved Domains (1) summary
-
- COG1025
Location:11 → 917
- Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
-
XM_017016187.2 → XP_016871676.1  insulin-degrading enzyme isoform X3
- UniProtKB/TrEMBL
-
A0A7I2V3E3
- Related
-
ENST00000678458.1
- Conserved Domains (1) summary
-
- COG1025
Location:11 → 917
- Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
-
XM_047425174.1 → XP_047281130.1  insulin-degrading enzyme isoform X6
- UniProtKB/TrEMBL
-
A0A7I2V373
- Related
- ENSP00000503274.1, ENST00000677434.1
-
XM_047425172.1 → XP_047281128.1  insulin-degrading enzyme isoform X4
-
XM_047425175.1 → XP_047281131.1  insulin-degrading enzyme isoform X7
-
XM_047425173.1 → XP_047281129.1  insulin-degrading enzyme isoform X5
Alternate T2T-CHM13v2.0
Genomic
-
NC_060934.1Â Alternate T2T-CHM13v2.0
- Range
-
93330970..93453429 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054365746.1 → XP_054221721.1  insulin-degrading enzyme isoform X3
-
XM_054365748.1 → XP_054221723.1  insulin-degrading enzyme isoform X1
-
XM_054365744.1 → XP_054221719.1  insulin-degrading enzyme isoform X2
-
XM_054365747.1 → XP_054221722.1  insulin-degrading enzyme isoform X3
-
XM_054365745.1 → XP_054221720.1  insulin-degrading enzyme isoform X3
-
XM_054365751.1 → XP_054221726.1  insulin-degrading enzyme isoform X6
- UniProtKB/TrEMBL
-
A0A7I2V373
-
XM_054365749.1 → XP_054221724.1  insulin-degrading enzyme isoform X4
-
XM_054365752.1 → XP_054221727.1  insulin-degrading enzyme isoform X7
-
XM_054365750.1 → XP_054221725.1  insulin-degrading enzyme isoform X5