JAML junction adhesion molecule like [Homo sapiens (human)] - Gene

Summary

Official Symbol: JAMLprovided by HGNC
Official Full Name: junction adhesion molecule likeprovided by HGNC
Primary source: HGNC:HGNC:19084
See related: Ensembl:ENSG00000160593 MIM:609770; AllianceGenome:HGNC:19084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AMICA; Gm638; AMICA1; CREA7-1; CREA7-4
Summary: Enables integrin binding activity and protein homodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and myeloid leukocyte migration. Located in bicellular tight junction; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in appendix (RPKM 34.6), spleen (RPKM 24.5) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q23.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (118193725..118225011, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (118210112..118241400, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (118064440..118095726, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment.
Title: JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment.
JAML promotes the antitumor role of tumor-resident CD8[+] T cells by facilitating their innate-like function in human lung cancer.
Title: JAML promotes the antitumor role of tumor-resident CD8(+) T cells by facilitating their innate-like function in human lung cancer.
Junctional adhesion molecule-like protein as a novel target for kaempferol to ameliorate lung adenocarcinoma.
Title: Junctional adhesion molecule-like protein as a novel target for kaempferol to ameliorate lung adenocarcinoma.
Junctional adhesion molecule-like protein promotes tumor progression via the Wnt/beta-catenin signaling pathway in lung adenocarcinoma.
Title: Junctional adhesion molecule-like protein promotes tumor progression via the Wnt/β-catenin signaling pathway in lung adenocarcinoma.
Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with Prognosis and Immune Infiltrates in Lung Adenocarcinoma.
Title: Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with Prognosis and Immune Infiltrates in Lung Adenocarcinoma.
JAML promotes CD8 and gammadelta T cell antitumor immunity and is a novel target for cancer immunotherapy.
Title: JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Title: Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Findings suggest that specific JAM family members play an important role in the transendothelial migration (TEM) of in vitro-generated mouse and human dendritic cells (DCs) from the inoculation site to regional lymph nodes (LNs) in DC-based cancer immunotherapy.
Title: Junctional adhesion molecules mediate transendothelial migration of dendritic cell vaccine in cancer immunotherapy.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Integrin activation is required for the dissociation of JAM-L-VLA-4 complexes and the accumulation of functional JAM-L dimers, which indicates that the leukocyte integrin VLA-4 controls JAM-L function in cis by controlling its dimerization state.
Title: JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484142

D11S4050E (e-PCR)
- UniSTS:153928

RH47232 (e-PCR)
- UniSTS:48478

AMICA__4295 (e-PCR)
- UniSTS:462727

G59558 (e-PCR)
- UniSTS:136862

STS-T86918 (e-PCR)
- UniSTS:55767

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in gamma-delta T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte extravasation	IBA Inferred from Biological aspect of Ancestor more info
involved_in monocyte extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil extravasation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation involved in wound healing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: junctional adhesion molecule-like

Names: adhesion molecule AMICA; adhesion molecule interacting with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098526.2 → NP_001091996.1 junctional adhesion molecule-like isoform 1 precursor

See identical proteins and their annotated locations for NP_001091996.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK097285, AP002800, AY138965, DC296115

Consensus CDS

CCDS41723.1

UniProtKB/Swiss-Prot

B0YIV1, B0YIV2, Q496M1, Q5DTC6, Q7Z499, Q86YT9, Q8N9I7, Q8NF70

UniProtKB/TrEMBL

E9PR26

Related

ENSP00000348635.5, ENST00000356289.10

Conserved Domains (2) summary

smart00410
Location:27 → 135

IG_like; Immunoglobulin like

pfam07686
Location:26 → 136

V-set; Immunoglobulin V-set domain
NM_001286570.2 → NP_001273499.1 junctional adhesion molecule-like isoform 3

See identical proteins and their annotated locations for NP_001273499.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).

Source sequence(s)

AK097285, AK298722, AP002800, BC100797

Consensus CDS

CCDS66240.1

UniProtKB/TrEMBL

Q496M2, Q496M4

Related

ENSP00000431218.1, ENST00000526620.5

Conserved Domains (2) summary

smart00410
Location:158 → 212

IG_like; Immunoglobulin like

pfam07686
Location:3 → 97

V-set; Immunoglobulin V-set domain
NM_001286571.2 → NP_001273500.1 junctional adhesion molecule-like isoform 3

See identical proteins and their annotated locations for NP_001273500.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).

Source sequence(s)

AK097285, AP002800, BC100797

Consensus CDS

CCDS66240.1

UniProtKB/TrEMBL

Q496M2, Q496M4

Related

ENSP00000431614.1, ENST00000526595.5

Conserved Domains (2) summary

smart00410
Location:158 → 212

IG_like; Immunoglobulin like

pfam07686
Location:3 → 97

V-set; Immunoglobulin V-set domain
NM_153206.3 → NP_694938.2 junctional adhesion molecule-like isoform 2

See identical proteins and their annotated locations for NP_694938.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AK094399, AK097285, AP002800, AW804077, DA090367

Consensus CDS

CCDS8391.1

UniProtKB/TrEMBL

E9PR26

Related

ENSP00000292067.7, ENST00000292067.11

Conserved Domains (2) summary

smart00410
Location:187 → 241

IG_like; Immunoglobulin like

pfam07686
Location:16 → 126

V-set; Immunoglobulin V-set domain

RNA

NR_104479.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks two exons in the 5' region, contains an alternate 5' terminal exon, and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK097285, AP002800, BC100795, BC100797